Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Welcome to Bioconductor
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prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2025-03-25 19:59:48.280655 INFO::Creating output folder.
## 2025-03-25 19:59:48.304443 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2025-03-25 19:59:48.407348 INFO::Summarized Experiment created.
## 2025-03-25 19:59:48.409961 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2025-03-25 19:59:54.560337 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2025-03-25 19:59:54.56311 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2025-03-25 19:59:56.084648 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2025-03-25 19:59:59.329483 INFO::Writing function arguments to log file
## 2025-03-25 19:59:59.352905 INFO::Verifying options selected are valid
## 2025-03-25 19:59:59.430787 INFO::Determining format of input files
## 2025-03-25 19:59:59.433796 INFO::Input format is data samples as columns and metadata samples as rows
## 2025-03-25 19:59:59.465303 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2025-03-25 19:59:59.469238 INFO::Filter data based on min abundance and min prevalence
## 2025-03-25 19:59:59.471744 INFO::Total samples in data: 102
## 2025-03-25 19:59:59.474139 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2025-03-25 19:59:59.491806 INFO::Total filtered features: 0
## 2025-03-25 19:59:59.494003 INFO::Filtered feature names from abundance and prevalence filtering:
## 2025-03-25 19:59:59.527689 INFO::Total filtered features with variance filtering: 0
## 2025-03-25 19:59:59.529653 INFO::Filtered feature names from variance filtering:
## 2025-03-25 19:59:59.53114 INFO::Running selected normalization method: NONE
## 2025-03-25 19:59:59.53262 INFO::Applying z-score to standardize continuous metadata
## 2025-03-25 19:59:59.555504 INFO::Running selected transform method: NONE
## 2025-03-25 19:59:59.557248 INFO::Running selected analysis method: LM
## 2025-03-25 19:59:59.565723 INFO::Fitting model to feature number 1, F1
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## 2025-03-25 20:00:00.550229 INFO::Fitting model to feature number 182, F188
## 2025-03-25 20:00:00.55515 INFO::Fitting model to feature number 183, F189
## 2025-03-25 20:00:00.560148 INFO::Fitting model to feature number 184, F190
## 2025-03-25 20:00:00.565136 INFO::Fitting model to feature number 185, F191
## 2025-03-25 20:00:00.570056 INFO::Fitting model to feature number 186, F192
## 2025-03-25 20:00:00.574969 INFO::Fitting model to feature number 187, F193
## 2025-03-25 20:00:00.579877 INFO::Fitting model to feature number 188, F194
## 2025-03-25 20:00:00.58507 INFO::Fitting model to feature number 189, F195
## 2025-03-25 20:00:00.591925 INFO::Fitting model to feature number 190, F196
## 2025-03-25 20:00:00.598682 INFO::Fitting model to feature number 191, F197
## 2025-03-25 20:00:00.605486 INFO::Fitting model to feature number 192, F198
## 2025-03-25 20:00:00.612411 INFO::Fitting model to feature number 193, F199
## 2025-03-25 20:00:00.619316 INFO::Fitting model to feature number 194, F200
## 2025-03-25 20:00:00.626203 INFO::Fitting model to feature number 195, F201
## 2025-03-25 20:00:00.633066 INFO::Fitting model to feature number 196, F202
## 2025-03-25 20:00:00.639949 INFO::Fitting model to feature number 197, F203
## 2025-03-25 20:00:00.646951 INFO::Fitting model to feature number 198, F204
## 2025-03-25 20:00:00.653621 INFO::Fitting model to feature number 199, F206
## 2025-03-25 20:00:00.65972 INFO::Fitting model to feature number 200, F207
## 2025-03-25 20:00:00.666075 INFO::Fitting model to feature number 201, F208
## 2025-03-25 20:00:00.67331 INFO::Fitting model to feature number 202, F209
## 2025-03-25 20:00:00.681792 INFO::Fitting model to feature number 203, F210
## 2025-03-25 20:00:00.689597 INFO::Fitting model to feature number 204, F211
## 2025-03-25 20:00:00.697205 INFO::Fitting model to feature number 205, F212
## 2025-03-25 20:00:00.704624 INFO::Fitting model to feature number 206, F213
## 2025-03-25 20:00:00.712177 INFO::Fitting model to feature number 207, F214
## 2025-03-25 20:00:00.720141 INFO::Fitting model to feature number 208, F215
## 2025-03-25 20:00:00.727631 INFO::Fitting model to feature number 209, F216
## 2025-03-25 20:00:00.735051 INFO::Fitting model to feature number 210, F217
## 2025-03-25 20:00:00.742292 INFO::Fitting model to feature number 211, F218
## 2025-03-25 20:00:00.749452 INFO::Fitting model to feature number 212, F219
## 2025-03-25 20:00:00.756465 INFO::Fitting model to feature number 213, F220
## 2025-03-25 20:00:00.763485 INFO::Fitting model to feature number 214, F221
## 2025-03-25 20:00:00.77067 INFO::Fitting model to feature number 215, F222
## 2025-03-25 20:00:00.777821 INFO::Fitting model to feature number 216, F223
## 2025-03-25 20:00:00.785005 INFO::Fitting model to feature number 217, F224
## 2025-03-25 20:00:00.790717 INFO::Fitting model to feature number 218, F225
## 2025-03-25 20:00:00.795438 INFO::Fitting model to feature number 219, F226
## 2025-03-25 20:00:00.80008 INFO::Fitting model to feature number 220, F227
## 2025-03-25 20:00:00.804848 INFO::Fitting model to feature number 221, F228
## 2025-03-25 20:00:00.809812 INFO::Fitting model to feature number 222, F229
## 2025-03-25 20:00:00.816618 INFO::Fitting model to feature number 223, F230
## 2025-03-25 20:00:00.822246 INFO::Fitting model to feature number 224, F231
## 2025-03-25 20:00:00.826989 INFO::Fitting model to feature number 225, F232
## 2025-03-25 20:00:00.832006 INFO::Fitting model to feature number 226, F233
## 2025-03-25 20:00:00.836735 INFO::Fitting model to feature number 227, F234
## 2025-03-25 20:00:00.841683 INFO::Fitting model to feature number 228, F235
## 2025-03-25 20:00:00.84649 INFO::Fitting model to feature number 229, F236
## 2025-03-25 20:00:00.851254 INFO::Fitting model to feature number 230, F237
## 2025-03-25 20:00:00.85627 INFO::Fitting model to feature number 231, F238
## 2025-03-25 20:00:00.861411 INFO::Fitting model to feature number 232, F239
## 2025-03-25 20:00:00.866143 INFO::Fitting model to feature number 233, F240
## 2025-03-25 20:00:00.871164 INFO::Fitting model to feature number 234, F241
## 2025-03-25 20:00:00.875889 INFO::Fitting model to feature number 235, F242
## 2025-03-25 20:00:00.880584 INFO::Fitting model to feature number 236, F243
## 2025-03-25 20:00:00.885352 INFO::Fitting model to feature number 237, F244
## 2025-03-25 20:00:00.889957 INFO::Fitting model to feature number 238, F245
## 2025-03-25 20:00:00.894565 INFO::Fitting model to feature number 239, F246
## 2025-03-25 20:00:00.89922 INFO::Fitting model to feature number 240, F247
## 2025-03-25 20:00:00.903814 INFO::Fitting model to feature number 241, F248
## 2025-03-25 20:00:00.90838 INFO::Fitting model to feature number 242, F249
## 2025-03-25 20:00:00.913131 INFO::Fitting model to feature number 243, F250
## 2025-03-25 20:00:00.920432 INFO::Fitting model to feature number 244, F252
## 2025-03-25 20:00:00.926644 INFO::Fitting model to feature number 245, F253
## 2025-03-25 20:00:00.931562 INFO::Fitting model to feature number 246, F254
## 2025-03-25 20:00:00.936322 INFO::Fitting model to feature number 247, F255
## 2025-03-25 20:00:00.94098 INFO::Fitting model to feature number 248, F256
## 2025-03-25 20:00:00.945663 INFO::Fitting model to feature number 249, F257
## 2025-03-25 20:00:00.950343 INFO::Fitting model to feature number 250, F259
## 2025-03-25 20:00:00.954975 INFO::Fitting model to feature number 251, F260
## 2025-03-25 20:00:00.959623 INFO::Fitting model to feature number 252, F261
## 2025-03-25 20:00:00.967422 INFO::Fitting model to feature number 253, F262
## 2025-03-25 20:00:00.975002 INFO::Fitting model to feature number 254, F263
## 2025-03-25 20:00:00.98231 INFO::Fitting model to feature number 255, F264
## 2025-03-25 20:00:00.988249 INFO::Fitting model to feature number 256, F265
## 2025-03-25 20:00:00.993535 INFO::Fitting model to feature number 257, F266
## 2025-03-25 20:00:00.998517 INFO::Fitting model to feature number 258, F267
## 2025-03-25 20:00:01.003433 INFO::Fitting model to feature number 259, F269
## 2025-03-25 20:00:01.008356 INFO::Fitting model to feature number 260, F270
## 2025-03-25 20:00:01.013394 INFO::Fitting model to feature number 261, F271
## 2025-03-25 20:00:01.018213 INFO::Fitting model to feature number 262, F272
## 2025-03-25 20:00:01.023053 INFO::Fitting model to feature number 263, F273
## 2025-03-25 20:00:01.027937 INFO::Fitting model to feature number 264, F274
## 2025-03-25 20:00:01.032808 INFO::Fitting model to feature number 265, F276
## 2025-03-25 20:00:01.037648 INFO::Fitting model to feature number 266, F277
## 2025-03-25 20:00:01.042497 INFO::Fitting model to feature number 267, F278
## 2025-03-25 20:00:01.04737 INFO::Fitting model to feature number 268, F279
## 2025-03-25 20:00:01.052325 INFO::Fitting model to feature number 269, F280
## 2025-03-25 20:00:01.057402 INFO::Fitting model to feature number 270, F281
## 2025-03-25 20:00:01.064794 INFO::Fitting model to feature number 271, F282
## 2025-03-25 20:00:01.072233 INFO::Fitting model to feature number 272, F283
## 2025-03-25 20:00:01.080088 INFO::Fitting model to feature number 273, F284
## 2025-03-25 20:00:01.087913 INFO::Fitting model to feature number 274, F285
## 2025-03-25 20:00:01.094926 INFO::Fitting model to feature number 275, F286
## 2025-03-25 20:00:01.101938 INFO::Fitting model to feature number 276, F287
## 2025-03-25 20:00:01.109346 INFO::Fitting model to feature number 277, F288
## 2025-03-25 20:00:01.116917 INFO::Fitting model to feature number 278, F289
## 2025-03-25 20:00:01.124616 INFO::Fitting model to feature number 279, F290
## 2025-03-25 20:00:01.132453 INFO::Fitting model to feature number 280, F292
## 2025-03-25 20:00:01.140231 INFO::Fitting model to feature number 281, F293
## 2025-03-25 20:00:01.148033 INFO::Fitting model to feature number 282, F294
## 2025-03-25 20:00:01.15574 INFO::Fitting model to feature number 283, F295
## 2025-03-25 20:00:01.163757 INFO::Fitting model to feature number 284, F296
## 2025-03-25 20:00:01.171884 INFO::Fitting model to feature number 285, F297
## 2025-03-25 20:00:01.17976 INFO::Fitting model to feature number 286, F298
## 2025-03-25 20:00:01.185912 INFO::Fitting model to feature number 287, F299
## 2025-03-25 20:00:01.19353 INFO::Fitting model to feature number 288, F300
## 2025-03-25 20:00:01.201465 INFO::Fitting model to feature number 289, F301
## 2025-03-25 20:00:01.209515 INFO::Fitting model to feature number 290, F302
## 2025-03-25 20:00:01.215402 INFO::Fitting model to feature number 291, F303
## 2025-03-25 20:00:01.220729 INFO::Fitting model to feature number 292, F304
## 2025-03-25 20:00:01.225932 INFO::Fitting model to feature number 293, F305
## 2025-03-25 20:00:01.231226 INFO::Fitting model to feature number 294, F306
## 2025-03-25 20:00:01.23653 INFO::Fitting model to feature number 295, F307
## 2025-03-25 20:00:01.241833 INFO::Fitting model to feature number 296, F308
## 2025-03-25 20:00:01.247926 INFO::Fitting model to feature number 297, F309
## 2025-03-25 20:00:01.256612 INFO::Fitting model to feature number 298, F310
## 2025-03-25 20:00:01.265278 INFO::Fitting model to feature number 299, F311
## 2025-03-25 20:00:01.273881 INFO::Fitting model to feature number 300, F312
## 2025-03-25 20:00:01.282474 INFO::Fitting model to feature number 301, F313
## 2025-03-25 20:00:01.291101 INFO::Fitting model to feature number 302, F315
## 2025-03-25 20:00:01.29975 INFO::Fitting model to feature number 303, F316
## 2025-03-25 20:00:01.308383 INFO::Fitting model to feature number 304, F317
## 2025-03-25 20:00:01.316361 INFO::Fitting model to feature number 305, F318
## 2025-03-25 20:00:01.324389 INFO::Fitting model to feature number 306, F319
## 2025-03-25 20:00:01.332378 INFO::Fitting model to feature number 307, F320
## 2025-03-25 20:00:01.340197 INFO::Fitting model to feature number 308, F321
## 2025-03-25 20:00:01.348086 INFO::Fitting model to feature number 309, F322
## 2025-03-25 20:00:01.356021 INFO::Fitting model to feature number 310, F323
## 2025-03-25 20:00:01.361973 INFO::Fitting model to feature number 311, F324
## 2025-03-25 20:00:01.36711 INFO::Fitting model to feature number 312, F325
## 2025-03-25 20:00:01.372374 INFO::Fitting model to feature number 313, F326
## 2025-03-25 20:00:01.377897 INFO::Fitting model to feature number 314, F327
## 2025-03-25 20:00:01.384809 INFO::Fitting model to feature number 315, F328
## 2025-03-25 20:00:01.391999 INFO::Fitting model to feature number 316, F329
## 2025-03-25 20:00:01.398005 INFO::Fitting model to feature number 317, F330
## 2025-03-25 20:00:01.403318 INFO::Fitting model to feature number 318, F331
## 2025-03-25 20:00:01.408388 INFO::Fitting model to feature number 319, F332
## 2025-03-25 20:00:01.413827 INFO::Fitting model to feature number 320, F333
## 2025-03-25 20:00:01.418962 INFO::Fitting model to feature number 321, F334
## 2025-03-25 20:00:01.423898 INFO::Fitting model to feature number 322, F335
## 2025-03-25 20:00:01.429289 INFO::Fitting model to feature number 323, F336
## 2025-03-25 20:00:01.434472 INFO::Fitting model to feature number 324, F337
## 2025-03-25 20:00:01.439229 INFO::Fitting model to feature number 325, F338
## 2025-03-25 20:00:01.444011 INFO::Fitting model to feature number 326, F339
## 2025-03-25 20:00:01.449182 INFO::Fitting model to feature number 327, F340
## 2025-03-25 20:00:01.454165 INFO::Fitting model to feature number 328, F342
## 2025-03-25 20:00:01.458869 INFO::Fitting model to feature number 329, F343
## 2025-03-25 20:00:01.46368 INFO::Fitting model to feature number 330, F344
## 2025-03-25 20:00:01.468397 INFO::Fitting model to feature number 331, F345
## 2025-03-25 20:00:01.473093 INFO::Fitting model to feature number 332, F346
## 2025-03-25 20:00:01.50586 INFO::Fitting model to feature number 333, F347
## 2025-03-25 20:00:01.513339 INFO::Fitting model to feature number 334, F348
## 2025-03-25 20:00:01.518596 INFO::Fitting model to feature number 335, F350
## 2025-03-25 20:00:01.524198 INFO::Fitting model to feature number 336, F351
## 2025-03-25 20:00:01.531729 INFO::Fitting model to feature number 337, F352
## 2025-03-25 20:00:01.539577 INFO::Fitting model to feature number 338, F353
## 2025-03-25 20:00:01.547172 INFO::Fitting model to feature number 339, F355
## 2025-03-25 20:00:01.553843 INFO::Fitting model to feature number 340, F356
## 2025-03-25 20:00:01.559009 INFO::Fitting model to feature number 341, F357
## 2025-03-25 20:00:01.563942 INFO::Fitting model to feature number 342, F358
## 2025-03-25 20:00:01.568731 INFO::Fitting model to feature number 343, F359
## 2025-03-25 20:00:01.575021 INFO::Fitting model to feature number 344, F360
## 2025-03-25 20:00:01.582071 INFO::Fitting model to feature number 345, F361
## 2025-03-25 20:00:01.589106 INFO::Fitting model to feature number 346, F362
## 2025-03-25 20:00:01.595969 INFO::Fitting model to feature number 347, F363
## 2025-03-25 20:00:01.602818 INFO::Fitting model to feature number 348, F364
## 2025-03-25 20:00:01.609501 INFO::Fitting model to feature number 349, F365
## 2025-03-25 20:00:01.616248 INFO::Fitting model to feature number 350, F366
## 2025-03-25 20:00:01.623061 INFO::Fitting model to feature number 351, F367
## 2025-03-25 20:00:01.629981 INFO::Fitting model to feature number 352, F368
## 2025-03-25 20:00:01.636823 INFO::Fitting model to feature number 353, F369
## 2025-03-25 20:00:01.643766 INFO::Fitting model to feature number 354, F370
## 2025-03-25 20:00:01.650722 INFO::Fitting model to feature number 355, F371
## 2025-03-25 20:00:01.657786 INFO::Fitting model to feature number 356, F372
## 2025-03-25 20:00:01.664763 INFO::Fitting model to feature number 357, F373
## 2025-03-25 20:00:01.671983 INFO::Fitting model to feature number 358, F374
## 2025-03-25 20:00:01.67939 INFO::Fitting model to feature number 359, F375
## 2025-03-25 20:00:01.684895 INFO::Fitting model to feature number 360, F376
## 2025-03-25 20:00:01.690425 INFO::Fitting model to feature number 361, F377
## 2025-03-25 20:00:01.697603 INFO::Fitting model to feature number 362, F378
## 2025-03-25 20:00:01.704287 INFO::Fitting model to feature number 363, F379
## 2025-03-25 20:00:01.708989 INFO::Fitting model to feature number 364, F380
## 2025-03-25 20:00:01.714113 INFO::Fitting model to feature number 365, F381
## 2025-03-25 20:00:01.718871 INFO::Fitting model to feature number 366, F382
## 2025-03-25 20:00:01.724022 INFO::Fitting model to feature number 367, F383
## 2025-03-25 20:00:01.729931 INFO::Fitting model to feature number 368, F384
## 2025-03-25 20:00:01.734909 INFO::Fitting model to feature number 369, F386
## 2025-03-25 20:00:01.739802 INFO::Fitting model to feature number 370, F387
## 2025-03-25 20:00:01.744733 INFO::Fitting model to feature number 371, F388
## 2025-03-25 20:00:01.749398 INFO::Fitting model to feature number 372, F389
## 2025-03-25 20:00:01.754125 INFO::Fitting model to feature number 373, F390
## 2025-03-25 20:00:01.758992 INFO::Fitting model to feature number 374, F391
## 2025-03-25 20:00:01.763787 INFO::Fitting model to feature number 375, F392
## 2025-03-25 20:00:01.768769 INFO::Fitting model to feature number 376, F393
## 2025-03-25 20:00:01.773664 INFO::Fitting model to feature number 377, F394
## 2025-03-25 20:00:01.780934 INFO::Fitting model to feature number 378, F395
## 2025-03-25 20:00:01.788167 INFO::Fitting model to feature number 379, F396
## 2025-03-25 20:00:01.795328 INFO::Fitting model to feature number 380, F397
## 2025-03-25 20:00:01.802531 INFO::Fitting model to feature number 381, F398
## 2025-03-25 20:00:01.809601 INFO::Fitting model to feature number 382, F399
## 2025-03-25 20:00:01.81672 INFO::Fitting model to feature number 383, F400
## 2025-03-25 20:00:01.823815 INFO::Fitting model to feature number 384, F401
## 2025-03-25 20:00:01.830926 INFO::Fitting model to feature number 385, F402
## 2025-03-25 20:00:01.838307 INFO::Fitting model to feature number 386, F403
## 2025-03-25 20:00:01.845672 INFO::Fitting model to feature number 387, F404
## 2025-03-25 20:00:01.852938 INFO::Fitting model to feature number 388, F406
## 2025-03-25 20:00:01.859974 INFO::Fitting model to feature number 389, F407
## 2025-03-25 20:00:01.866996 INFO::Fitting model to feature number 390, F408
## 2025-03-25 20:00:01.87392 INFO::Fitting model to feature number 391, F409
## 2025-03-25 20:00:01.88094 INFO::Fitting model to feature number 392, F410
## 2025-03-25 20:00:01.887952 INFO::Fitting model to feature number 393, F411
## 2025-03-25 20:00:01.895009 INFO::Fitting model to feature number 394, F412
## 2025-03-25 20:00:01.90319 INFO::Fitting model to feature number 395, F413
## 2025-03-25 20:00:01.911586 INFO::Fitting model to feature number 396, F414
## 2025-03-25 20:00:01.918801 INFO::Fitting model to feature number 397, F415
## 2025-03-25 20:00:01.926075 INFO::Fitting model to feature number 398, F416
## 2025-03-25 20:00:01.933297 INFO::Fitting model to feature number 399, F417
## 2025-03-25 20:00:01.940508 INFO::Fitting model to feature number 400, F418
## 2025-03-25 20:00:01.947757 INFO::Fitting model to feature number 401, F419
## 2025-03-25 20:00:01.95501 INFO::Fitting model to feature number 402, F420
## 2025-03-25 20:00:01.96116 INFO::Fitting model to feature number 403, F421
## 2025-03-25 20:00:01.965885 INFO::Fitting model to feature number 404, F422
## 2025-03-25 20:00:01.970525 INFO::Fitting model to feature number 405, F423
## 2025-03-25 20:00:01.975276 INFO::Fitting model to feature number 406, F425
## 2025-03-25 20:00:01.980774 INFO::Fitting model to feature number 407, F426
## 2025-03-25 20:00:01.988416 INFO::Fitting model to feature number 408, F428
## 2025-03-25 20:00:01.997194 INFO::Fitting model to feature number 409, F429
## 2025-03-25 20:00:02.004939 INFO::Fitting model to feature number 410, F430
## 2025-03-25 20:00:02.010805 INFO::Fitting model to feature number 411, F431
## 2025-03-25 20:00:02.017037 INFO::Fitting model to feature number 412, F432
## 2025-03-25 20:00:02.024539 INFO::Fitting model to feature number 413, F433
## 2025-03-25 20:00:02.031704 INFO::Fitting model to feature number 414, F434
## 2025-03-25 20:00:02.038825 INFO::Fitting model to feature number 415, F435
## 2025-03-25 20:00:02.046096 INFO::Fitting model to feature number 416, F436
## 2025-03-25 20:00:02.053749 INFO::Fitting model to feature number 417, F437
## 2025-03-25 20:00:02.061679 INFO::Fitting model to feature number 418, F438
## 2025-03-25 20:00:02.071084 INFO::Fitting model to feature number 419, F439
## 2025-03-25 20:00:02.079065 INFO::Fitting model to feature number 420, F440
## 2025-03-25 20:00:02.086378 INFO::Fitting model to feature number 421, F441
## 2025-03-25 20:00:02.093406 INFO::Fitting model to feature number 422, F442
## 2025-03-25 20:00:02.10034 INFO::Fitting model to feature number 423, F443
## 2025-03-25 20:00:02.107468 INFO::Fitting model to feature number 424, F444
## 2025-03-25 20:00:02.11435 INFO::Fitting model to feature number 425, F445
## 2025-03-25 20:00:02.120966 INFO::Fitting model to feature number 426, F446
## 2025-03-25 20:00:02.127407 INFO::Fitting model to feature number 427, F447
## 2025-03-25 20:00:02.133865 INFO::Fitting model to feature number 428, F448
## 2025-03-25 20:00:02.138607 INFO::Fitting model to feature number 429, F449
## 2025-03-25 20:00:02.143246 INFO::Fitting model to feature number 430, F450
## 2025-03-25 20:00:02.147872 INFO::Fitting model to feature number 431, F451
## 2025-03-25 20:00:02.152535 INFO::Fitting model to feature number 432, F452
## 2025-03-25 20:00:02.157164 INFO::Fitting model to feature number 433, F454
## 2025-03-25 20:00:02.161772 INFO::Fitting model to feature number 434, F455
## 2025-03-25 20:00:02.166415 INFO::Fitting model to feature number 435, F456
## 2025-03-25 20:00:02.170896 INFO::Fitting model to feature number 436, F457
## 2025-03-25 20:00:02.175342 INFO::Fitting model to feature number 437, F458
## 2025-03-25 20:00:02.179823 INFO::Fitting model to feature number 438, F459
## 2025-03-25 20:00:02.184342 INFO::Fitting model to feature number 439, F461
## 2025-03-25 20:00:02.18873 INFO::Fitting model to feature number 440, F462
## 2025-03-25 20:00:02.193135 INFO::Fitting model to feature number 441, F463
## 2025-03-25 20:00:02.199317 INFO::Fitting model to feature number 442, F464
## 2025-03-25 20:00:02.206594 INFO::Fitting model to feature number 443, F465
## 2025-03-25 20:00:02.215124 INFO::Fitting model to feature number 444, F466
## 2025-03-25 20:00:02.223642 INFO::Fitting model to feature number 445, F467
## 2025-03-25 20:00:02.232405 INFO::Fitting model to feature number 446, F468
## 2025-03-25 20:00:02.240969 INFO::Fitting model to feature number 447, F469
## 2025-03-25 20:00:02.249147 INFO::Fitting model to feature number 448, F470
## 2025-03-25 20:00:02.256776 INFO::Fitting model to feature number 449, F471
## 2025-03-25 20:00:02.263968 INFO::Fitting model to feature number 450, F474
## 2025-03-25 20:00:02.271476 INFO::Fitting model to feature number 451, F475
## 2025-03-25 20:00:02.279055 INFO::Fitting model to feature number 452, F476
## 2025-03-25 20:00:02.285938 INFO::Fitting model to feature number 453, F477
## 2025-03-25 20:00:02.29291 INFO::Fitting model to feature number 454, F478
## 2025-03-25 20:00:02.299713 INFO::Fitting model to feature number 455, F479
## 2025-03-25 20:00:02.306755 INFO::Fitting model to feature number 456, F480
## 2025-03-25 20:00:02.313551 INFO::Fitting model to feature number 457, F481
## 2025-03-25 20:00:02.320536 INFO::Fitting model to feature number 458, F482
## 2025-03-25 20:00:02.327603 INFO::Fitting model to feature number 459, F483
## 2025-03-25 20:00:02.334638 INFO::Fitting model to feature number 460, F484
## 2025-03-25 20:00:02.341779 INFO::Fitting model to feature number 461, F485
## 2025-03-25 20:00:02.349216 INFO::Fitting model to feature number 462, F486
## 2025-03-25 20:00:02.356899 INFO::Fitting model to feature number 463, F487
## 2025-03-25 20:00:02.364119 INFO::Fitting model to feature number 464, F488
## 2025-03-25 20:00:02.371309 INFO::Fitting model to feature number 465, F489
## 2025-03-25 20:00:02.379021 INFO::Fitting model to feature number 466, F490
## 2025-03-25 20:00:02.387045 INFO::Fitting model to feature number 467, F491
## 2025-03-25 20:00:02.394992 INFO::Fitting model to feature number 468, F492
## 2025-03-25 20:00:02.402941 INFO::Fitting model to feature number 469, F493
## 2025-03-25 20:00:02.410725 INFO::Fitting model to feature number 470, F494
## 2025-03-25 20:00:02.418505 INFO::Fitting model to feature number 471, F495
## 2025-03-25 20:00:02.425949 INFO::Fitting model to feature number 472, F496
## 2025-03-25 20:00:02.431165 INFO::Fitting model to feature number 473, F497
## 2025-03-25 20:00:02.43662 INFO::Fitting model to feature number 474, F498
## 2025-03-25 20:00:02.441259 INFO::Fitting model to feature number 475, F499
## 2025-03-25 20:00:02.445974 INFO::Fitting model to feature number 476, F500
## 2025-03-25 20:00:02.450676 INFO::Fitting model to feature number 477, F501
## 2025-03-25 20:00:02.456 INFO::Fitting model to feature number 478, F502
## 2025-03-25 20:00:02.461126 INFO::Fitting model to feature number 479, F503
## 2025-03-25 20:00:02.465976 INFO::Fitting model to feature number 480, F504
## 2025-03-25 20:00:02.470868 INFO::Fitting model to feature number 481, F505
## 2025-03-25 20:00:02.475627 INFO::Fitting model to feature number 482, F506
## 2025-03-25 20:00:02.480755 INFO::Fitting model to feature number 483, F507
## 2025-03-25 20:00:02.485842 INFO::Fitting model to feature number 484, F508
## 2025-03-25 20:00:02.490507 INFO::Fitting model to feature number 485, F509
## 2025-03-25 20:00:02.495317 INFO::Fitting model to feature number 486, F510
## 2025-03-25 20:00:02.500122 INFO::Fitting model to feature number 487, F511
## 2025-03-25 20:00:02.504868 INFO::Fitting model to feature number 488, F512
## 2025-03-25 20:00:02.509728 INFO::Fitting model to feature number 489, F513
## 2025-03-25 20:00:02.514608 INFO::Fitting model to feature number 490, F514
## 2025-03-25 20:00:02.519282 INFO::Fitting model to feature number 491, F515
## 2025-03-25 20:00:02.52665 INFO::Fitting model to feature number 492, F516
## 2025-03-25 20:00:02.534082 INFO::Fitting model to feature number 493, F517
## 2025-03-25 20:00:02.541532 INFO::Fitting model to feature number 494, F518
## 2025-03-25 20:00:02.548953 INFO::Fitting model to feature number 495, F519
## 2025-03-25 20:00:02.55375 INFO::Fitting model to feature number 496, F520
## 2025-03-25 20:00:02.558477 INFO::Fitting model to feature number 497, F521
## 2025-03-25 20:00:02.563132 INFO::Fitting model to feature number 498, F522
## 2025-03-25 20:00:02.56772 INFO::Fitting model to feature number 499, F523
## 2025-03-25 20:00:02.572398 INFO::Fitting model to feature number 500, F524
## 2025-03-25 20:00:02.580278 INFO::Fitting model to feature number 501, F525
## 2025-03-25 20:00:02.58822 INFO::Fitting model to feature number 502, F526
## 2025-03-25 20:00:02.596171 INFO::Fitting model to feature number 503, F527
## 2025-03-25 20:00:02.60381 INFO::Fitting model to feature number 504, F528
## 2025-03-25 20:00:02.611327 INFO::Fitting model to feature number 505, F529
## 2025-03-25 20:00:02.619795 INFO::Fitting model to feature number 506, F530
## 2025-03-25 20:00:02.626783 INFO::Fitting model to feature number 507, F531
## 2025-03-25 20:00:02.634263 INFO::Fitting model to feature number 508, F532
## 2025-03-25 20:00:02.64183 INFO::Fitting model to feature number 509, F533
## 2025-03-25 20:00:02.649455 INFO::Fitting model to feature number 510, F534
## 2025-03-25 20:00:02.657213 INFO::Fitting model to feature number 511, F535
## 2025-03-25 20:00:02.664932 INFO::Fitting model to feature number 512, F536
## 2025-03-25 20:00:02.672741 INFO::Fitting model to feature number 513, F537
## 2025-03-25 20:00:02.680321 INFO::Fitting model to feature number 514, F539
## 2025-03-25 20:00:02.68804 INFO::Fitting model to feature number 515, F540
## 2025-03-25 20:00:02.695724 INFO::Fitting model to feature number 516, F541
## 2025-03-25 20:00:02.703489 INFO::Fitting model to feature number 517, F543
## 2025-03-25 20:00:02.711272 INFO::Fitting model to feature number 518, F544
## 2025-03-25 20:00:02.719208 INFO::Fitting model to feature number 519, F545
## 2025-03-25 20:00:02.727134 INFO::Fitting model to feature number 520, F546
## 2025-03-25 20:00:02.735059 INFO::Fitting model to feature number 521, F547
## 2025-03-25 20:00:02.74256 INFO::Fitting model to feature number 522, F548
## 2025-03-25 20:00:02.749701 INFO::Fitting model to feature number 523, F549
## 2025-03-25 20:00:02.754589 INFO::Fitting model to feature number 524, F550
## 2025-03-25 20:00:02.760653 INFO::Fitting model to feature number 525, F551
## 2025-03-25 20:00:02.765587 INFO::Fitting model to feature number 526, F552
## 2025-03-25 20:00:02.770411 INFO::Fitting model to feature number 527, F553
## 2025-03-25 20:00:02.775267 INFO::Fitting model to feature number 528, F554
## 2025-03-25 20:00:02.780278 INFO::Fitting model to feature number 529, F555
## 2025-03-25 20:00:02.7863 INFO::Fitting model to feature number 530, F556
## 2025-03-25 20:00:02.792999 INFO::Fitting model to feature number 531, F557
## 2025-03-25 20:00:02.798366 INFO::Fitting model to feature number 532, F558
## 2025-03-25 20:00:02.803444 INFO::Fitting model to feature number 533, F559
## 2025-03-25 20:00:02.808626 INFO::Fitting model to feature number 534, F560
## 2025-03-25 20:00:02.813501 INFO::Fitting model to feature number 535, F561
## 2025-03-25 20:00:02.818323 INFO::Fitting model to feature number 536, F562
## 2025-03-25 20:00:02.823522 INFO::Fitting model to feature number 537, F563
## 2025-03-25 20:00:02.831481 INFO::Fitting model to feature number 538, F564
## 2025-03-25 20:00:02.840018 INFO::Fitting model to feature number 539, F566
## 2025-03-25 20:00:02.84567 INFO::Fitting model to feature number 540, F567
## 2025-03-25 20:00:02.853321 INFO::Fitting model to feature number 541, F568
## 2025-03-25 20:00:02.860971 INFO::Fitting model to feature number 542, F569
## 2025-03-25 20:00:02.867238 INFO::Fitting model to feature number 543, F570
## 2025-03-25 20:00:02.872363 INFO::Fitting model to feature number 544, F571
## 2025-03-25 20:00:02.877443 INFO::Fitting model to feature number 545, F572
## 2025-03-25 20:00:02.88291 INFO::Fitting model to feature number 546, F573
## 2025-03-25 20:00:02.888121 INFO::Fitting model to feature number 547, F574
## 2025-03-25 20:00:02.89298 INFO::Fitting model to feature number 548, F575
## 2025-03-25 20:00:02.89859 INFO::Fitting model to feature number 549, F576
## 2025-03-25 20:00:02.903764 INFO::Fitting model to feature number 550, F577
## 2025-03-25 20:00:02.908655 INFO::Fitting model to feature number 551, F578
## 2025-03-25 20:00:02.913515 INFO::Fitting model to feature number 552, F579
## 2025-03-25 20:00:02.920423 INFO::Fitting model to feature number 553, F580
## 2025-03-25 20:00:02.928017 INFO::Fitting model to feature number 554, F581
## 2025-03-25 20:00:02.93585 INFO::Fitting model to feature number 555, F582
## 2025-03-25 20:00:02.943603 INFO::Fitting model to feature number 556, F583
## 2025-03-25 20:00:02.951363 INFO::Fitting model to feature number 557, F584
## 2025-03-25 20:00:02.959698 INFO::Fitting model to feature number 558, F585
## 2025-03-25 20:00:02.967552 INFO::Fitting model to feature number 559, F586
## 2025-03-25 20:00:02.975156 INFO::Fitting model to feature number 560, F587
## 2025-03-25 20:00:02.982776 INFO::Fitting model to feature number 561, F588
## 2025-03-25 20:00:02.990466 INFO::Fitting model to feature number 562, F589
## 2025-03-25 20:00:02.998107 INFO::Fitting model to feature number 563, F590
## 2025-03-25 20:00:03.006046 INFO::Fitting model to feature number 564, F591
## 2025-03-25 20:00:03.014401 INFO::Fitting model to feature number 565, F592
## 2025-03-25 20:00:03.019359 INFO::Fitting model to feature number 566, F593
## 2025-03-25 20:00:03.024484 INFO::Fitting model to feature number 567, F594
## 2025-03-25 20:00:03.030885 INFO::Fitting model to feature number 568, F595
## 2025-03-25 20:00:03.038129 INFO::Fitting model to feature number 569, F596
## 2025-03-25 20:00:03.044304 INFO::Fitting model to feature number 570, F597
## 2025-03-25 20:00:03.049052 INFO::Fitting model to feature number 571, F598
## 2025-03-25 20:00:03.053672 INFO::Fitting model to feature number 572, F599
## 2025-03-25 20:00:03.058308 INFO::Fitting model to feature number 573, F600
## 2025-03-25 20:00:03.066629 INFO::Fitting model to feature number 574, F601
## 2025-03-25 20:00:03.074264 INFO::Fitting model to feature number 575, F602
## 2025-03-25 20:00:03.081927 INFO::Fitting model to feature number 576, F603
## 2025-03-25 20:00:03.089738 INFO::Fitting model to feature number 577, F605
## 2025-03-25 20:00:03.097086 INFO::Fitting model to feature number 578, F606
## 2025-03-25 20:00:03.104493 INFO::Fitting model to feature number 579, F607
## 2025-03-25 20:00:03.111832 INFO::Fitting model to feature number 580, F608
## 2025-03-25 20:00:03.119195 INFO::Fitting model to feature number 581, F609
## 2025-03-25 20:00:03.126553 INFO::Fitting model to feature number 582, F610
## 2025-03-25 20:00:03.13378 INFO::Fitting model to feature number 583, F611
## 2025-03-25 20:00:03.141086 INFO::Fitting model to feature number 584, F612
## 2025-03-25 20:00:03.148306 INFO::Fitting model to feature number 585, F613
## 2025-03-25 20:00:03.155481 INFO::Fitting model to feature number 586, F614
## 2025-03-25 20:00:03.162638 INFO::Fitting model to feature number 587, F615
## 2025-03-25 20:00:03.169816 INFO::Fitting model to feature number 588, F616
## 2025-03-25 20:00:03.177255 INFO::Fitting model to feature number 589, F617
## 2025-03-25 20:00:03.185159 INFO::Fitting model to feature number 590, F618
## 2025-03-25 20:00:03.193044 INFO::Fitting model to feature number 591, F619
## 2025-03-25 20:00:03.200617 INFO::Fitting model to feature number 592, F620
## 2025-03-25 20:00:03.208688 INFO::Fitting model to feature number 593, F621
## 2025-03-25 20:00:03.216098 INFO::Fitting model to feature number 594, F622
## 2025-03-25 20:00:03.224322 INFO::Fitting model to feature number 595, F623
## 2025-03-25 20:00:03.232392 INFO::Fitting model to feature number 596, F624
## 2025-03-25 20:00:03.240384 INFO::Fitting model to feature number 597, F625
## 2025-03-25 20:00:03.247723 INFO::Fitting model to feature number 598, F626
## 2025-03-25 20:00:03.254962 INFO::Fitting model to feature number 599, F627
## 2025-03-25 20:00:03.26234 INFO::Fitting model to feature number 600, F628
## 2025-03-25 20:00:03.270682 INFO::Fitting model to feature number 601, F629
## 2025-03-25 20:00:03.276943 INFO::Fitting model to feature number 602, F630
## 2025-03-25 20:00:03.282192 INFO::Fitting model to feature number 603, F631
## 2025-03-25 20:00:03.287214 INFO::Fitting model to feature number 604, F632
## 2025-03-25 20:00:03.292124 INFO::Fitting model to feature number 605, F633
## 2025-03-25 20:00:03.297675 INFO::Fitting model to feature number 606, F634
## 2025-03-25 20:00:03.30327 INFO::Fitting model to feature number 607, F635
## 2025-03-25 20:00:03.310795 INFO::Fitting model to feature number 608, F636
## 2025-03-25 20:00:03.318902 INFO::Fitting model to feature number 609, F637
## 2025-03-25 20:00:03.326314 INFO::Fitting model to feature number 610, F638
## 2025-03-25 20:00:03.331513 INFO::Fitting model to feature number 611, F639
## 2025-03-25 20:00:03.337301 INFO::Fitting model to feature number 612, F640
## 2025-03-25 20:00:03.343013 INFO::Fitting model to feature number 613, F641
## 2025-03-25 20:00:03.348148 INFO::Fitting model to feature number 614, F642
## 2025-03-25 20:00:03.352944 INFO::Fitting model to feature number 615, F643
## 2025-03-25 20:00:03.357822 INFO::Fitting model to feature number 616, F644
## 2025-03-25 20:00:03.362667 INFO::Fitting model to feature number 617, F645
## 2025-03-25 20:00:03.367441 INFO::Fitting model to feature number 618, F646
## 2025-03-25 20:00:03.372363 INFO::Fitting model to feature number 619, F647
## 2025-03-25 20:00:03.377606 INFO::Fitting model to feature number 620, F648
## 2025-03-25 20:00:03.382443 INFO::Fitting model to feature number 621, F649
## 2025-03-25 20:00:03.388472 INFO::Fitting model to feature number 622, F650
## 2025-03-25 20:00:03.393268 INFO::Fitting model to feature number 623, F651
## 2025-03-25 20:00:03.398155 INFO::Fitting model to feature number 624, F652
## 2025-03-25 20:00:03.403036 INFO::Fitting model to feature number 625, F653
## 2025-03-25 20:00:03.407799 INFO::Fitting model to feature number 626, F654
## 2025-03-25 20:00:03.412772 INFO::Fitting model to feature number 627, F655
## 2025-03-25 20:00:03.418081 INFO::Fitting model to feature number 628, F656
## 2025-03-25 20:00:03.422929 INFO::Fitting model to feature number 629, F657
## 2025-03-25 20:00:03.427991 INFO::Fitting model to feature number 630, F658
## 2025-03-25 20:00:03.433178 INFO::Fitting model to feature number 631, F659
## 2025-03-25 20:00:03.437906 INFO::Fitting model to feature number 632, F660
## 2025-03-25 20:00:03.442623 INFO::Fitting model to feature number 633, F661
## 2025-03-25 20:00:03.447335 INFO::Fitting model to feature number 634, F662
## 2025-03-25 20:00:03.454035 INFO::Fitting model to feature number 635, F663
## 2025-03-25 20:00:03.46148 INFO::Fitting model to feature number 636, F664
## 2025-03-25 20:00:03.469385 INFO::Fitting model to feature number 637, F665
## 2025-03-25 20:00:03.476967 INFO::Fitting model to feature number 638, F666
## 2025-03-25 20:00:03.484719 INFO::Fitting model to feature number 639, F667
## 2025-03-25 20:00:03.492455 INFO::Fitting model to feature number 640, F668
## 2025-03-25 20:00:03.500152 INFO::Fitting model to feature number 641, F669
## 2025-03-25 20:00:03.507693 INFO::Fitting model to feature number 642, F670
## 2025-03-25 20:00:03.515305 INFO::Fitting model to feature number 643, F671
## 2025-03-25 20:00:03.523166 INFO::Fitting model to feature number 644, F672
## 2025-03-25 20:00:03.529638 INFO::Fitting model to feature number 645, F673
## 2025-03-25 20:00:03.534978 INFO::Fitting model to feature number 646, F674
## 2025-03-25 20:00:03.539781 INFO::Fitting model to feature number 647, F675
## 2025-03-25 20:00:03.546062 INFO::Fitting model to feature number 648, F676
## 2025-03-25 20:00:03.553173 INFO::Fitting model to feature number 649, F677
## 2025-03-25 20:00:03.559458 INFO::Fitting model to feature number 650, F678
## 2025-03-25 20:00:03.566153 INFO::Fitting model to feature number 651, F679
## 2025-03-25 20:00:03.571048 INFO::Fitting model to feature number 652, F680
## 2025-03-25 20:00:03.577132 INFO::Fitting model to feature number 653, F681
## 2025-03-25 20:00:03.582112 INFO::Fitting model to feature number 654, F682
## 2025-03-25 20:00:03.587064 INFO::Fitting model to feature number 655, F683
## 2025-03-25 20:00:03.591873 INFO::Fitting model to feature number 656, F684
## 2025-03-25 20:00:03.597049 INFO::Fitting model to feature number 657, F685
## 2025-03-25 20:00:03.601868 INFO::Fitting model to feature number 658, F686
## 2025-03-25 20:00:03.606951 INFO::Fitting model to feature number 659, F687
## 2025-03-25 20:00:03.612156 INFO::Fitting model to feature number 660, F688
## 2025-03-25 20:00:03.617617 INFO::Fitting model to feature number 661, F689
## 2025-03-25 20:00:03.622566 INFO::Fitting model to feature number 662, F690
## 2025-03-25 20:00:03.62769 INFO::Fitting model to feature number 663, F691
## 2025-03-25 20:00:03.633234 INFO::Fitting model to feature number 664, F692
## 2025-03-25 20:00:03.63934 INFO::Fitting model to feature number 665, F693
## 2025-03-25 20:00:03.646604 INFO::Fitting model to feature number 666, F694
## 2025-03-25 20:00:03.653326 INFO::Fitting model to feature number 667, F695
## 2025-03-25 20:00:03.658483 INFO::Fitting model to feature number 668, F696
## 2025-03-25 20:00:03.663258 INFO::Fitting model to feature number 669, F697
## 2025-03-25 20:00:03.691766 INFO::Fitting model to feature number 670, F698
## 2025-03-25 20:00:03.696921 INFO::Fitting model to feature number 671, F699
## 2025-03-25 20:00:03.702231 INFO::Fitting model to feature number 672, F700
## 2025-03-25 20:00:03.707771 INFO::Fitting model to feature number 673, F701
## 2025-03-25 20:00:03.713078 INFO::Fitting model to feature number 674, F702
## 2025-03-25 20:00:03.718 INFO::Fitting model to feature number 675, F704
## 2025-03-25 20:00:03.723379 INFO::Fitting model to feature number 676, F705
## 2025-03-25 20:00:03.728282 INFO::Fitting model to feature number 677, F706
## 2025-03-25 20:00:03.733234 INFO::Fitting model to feature number 678, F707
## 2025-03-25 20:00:03.738101 INFO::Fitting model to feature number 679, F708
## 2025-03-25 20:00:03.743483 INFO::Fitting model to feature number 680, F709
## 2025-03-25 20:00:03.749836 INFO::Fitting model to feature number 681, F710
## 2025-03-25 20:00:03.757049 INFO::Fitting model to feature number 682, F711
## 2025-03-25 20:00:03.764246 INFO::Fitting model to feature number 683, F712
## 2025-03-25 20:00:03.771622 INFO::Fitting model to feature number 684, F713
## 2025-03-25 20:00:03.779109 INFO::Fitting model to feature number 685, F714
## 2025-03-25 20:00:03.786629 INFO::Fitting model to feature number 686, F715
## 2025-03-25 20:00:03.793857 INFO::Fitting model to feature number 687, F716
## 2025-03-25 20:00:03.798402 INFO::Fitting model to feature number 688, F717
## 2025-03-25 20:00:03.802925 INFO::Fitting model to feature number 689, F718
## 2025-03-25 20:00:03.807468 INFO::Fitting model to feature number 690, F719
## 2025-03-25 20:00:03.813467 INFO::Fitting model to feature number 691, F720
## 2025-03-25 20:00:03.82033 INFO::Fitting model to feature number 692, F721
## 2025-03-25 20:00:03.827234 INFO::Fitting model to feature number 693, F722
## 2025-03-25 20:00:03.834099 INFO::Fitting model to feature number 694, F723
## 2025-03-25 20:00:03.841299 INFO::Fitting model to feature number 695, F724
## 2025-03-25 20:00:03.848224 INFO::Fitting model to feature number 696, F725
## 2025-03-25 20:00:03.85512 INFO::Fitting model to feature number 697, F726
## 2025-03-25 20:00:03.861807 INFO::Fitting model to feature number 698, F727
## 2025-03-25 20:00:03.868203 INFO::Fitting model to feature number 699, F728
## 2025-03-25 20:00:03.874532 INFO::Fitting model to feature number 700, F729
## 2025-03-25 20:00:03.881597 INFO::Fitting model to feature number 701, F730
## 2025-03-25 20:00:03.889184 INFO::Fitting model to feature number 702, F731
## 2025-03-25 20:00:03.896523 INFO::Fitting model to feature number 703, F732
## 2025-03-25 20:00:03.904055 INFO::Fitting model to feature number 704, F733
## 2025-03-25 20:00:03.911269 INFO::Fitting model to feature number 705, F734
## 2025-03-25 20:00:03.918731 INFO::Fitting model to feature number 706, F735
## 2025-03-25 20:00:03.925649 INFO::Fitting model to feature number 707, F736
## 2025-03-25 20:00:03.932241 INFO::Fitting model to feature number 708, F737
## 2025-03-25 20:00:03.938869 INFO::Fitting model to feature number 709, F739
## 2025-03-25 20:00:03.946157 INFO::Fitting model to feature number 710, F740
## 2025-03-25 20:00:03.953403 INFO::Fitting model to feature number 711, F741
## 2025-03-25 20:00:03.960771 INFO::Fitting model to feature number 712, F742
## 2025-03-25 20:00:03.967164 INFO::Fitting model to feature number 713, F743
## 2025-03-25 20:00:03.971703 INFO::Fitting model to feature number 714, F744
## 2025-03-25 20:00:03.976183 INFO::Fitting model to feature number 715, F745
## 2025-03-25 20:00:03.980617 INFO::Fitting model to feature number 716, F746
## 2025-03-25 20:00:03.985083 INFO::Fitting model to feature number 717, F747
## 2025-03-25 20:00:03.989426 INFO::Fitting model to feature number 718, F748
## 2025-03-25 20:00:03.995637 INFO::Fitting model to feature number 719, F749
## 2025-03-25 20:00:04.002468 INFO::Fitting model to feature number 720, F750
## 2025-03-25 20:00:04.009372 INFO::Fitting model to feature number 721, F751
## 2025-03-25 20:00:04.014829 INFO::Fitting model to feature number 722, F752
## 2025-03-25 20:00:04.019245 INFO::Fitting model to feature number 723, F753
## 2025-03-25 20:00:04.023526 INFO::Fitting model to feature number 724, F754
## 2025-03-25 20:00:04.027773 INFO::Fitting model to feature number 725, F755
## 2025-03-25 20:00:04.034299 INFO::Fitting model to feature number 726, F756
## 2025-03-25 20:00:04.041277 INFO::Fitting model to feature number 727, F757
## 2025-03-25 20:00:04.048266 INFO::Fitting model to feature number 728, F758
## 2025-03-25 20:00:04.055217 INFO::Fitting model to feature number 729, F759
## 2025-03-25 20:00:04.062573 INFO::Fitting model to feature number 730, F760
## 2025-03-25 20:00:04.069811 INFO::Fitting model to feature number 731, F761
## 2025-03-25 20:00:04.076894 INFO::Fitting model to feature number 732, F762
## 2025-03-25 20:00:04.08389 INFO::Fitting model to feature number 733, F763
## 2025-03-25 20:00:04.090815 INFO::Fitting model to feature number 734, F764
## 2025-03-25 20:00:04.097969 INFO::Fitting model to feature number 735, F765
## 2025-03-25 20:00:04.105251 INFO::Fitting model to feature number 736, F766
## 2025-03-25 20:00:04.110995 INFO::Fitting model to feature number 737, F767
## 2025-03-25 20:00:04.115619 INFO::Fitting model to feature number 738, F768
## 2025-03-25 20:00:04.12019 INFO::Fitting model to feature number 739, F769
## 2025-03-25 20:00:04.124787 INFO::Fitting model to feature number 740, F770
## 2025-03-25 20:00:04.129821 INFO::Fitting model to feature number 741, F771
## 2025-03-25 20:00:04.13461 INFO::Fitting model to feature number 742, F772
## 2025-03-25 20:00:04.139709 INFO::Fitting model to feature number 743, F773
## 2025-03-25 20:00:04.146316 INFO::Fitting model to feature number 744, F774
## 2025-03-25 20:00:04.153013 INFO::Fitting model to feature number 745, F775
## 2025-03-25 20:00:04.159765 INFO::Fitting model to feature number 746, F776
## 2025-03-25 20:00:04.166379 INFO::Fitting model to feature number 747, F777
## 2025-03-25 20:00:04.172997 INFO::Fitting model to feature number 748, F778
## 2025-03-25 20:00:04.180261 INFO::Fitting model to feature number 749, F779
## 2025-03-25 20:00:04.187825 INFO::Fitting model to feature number 750, F780
## 2025-03-25 20:00:04.195099 INFO::Fitting model to feature number 751, F781
## 2025-03-25 20:00:04.202603 INFO::Fitting model to feature number 752, F782
## 2025-03-25 20:00:04.209979 INFO::Fitting model to feature number 753, F783
## 2025-03-25 20:00:04.216867 INFO::Fitting model to feature number 754, F784
## 2025-03-25 20:00:04.221641 INFO::Fitting model to feature number 755, F785
## 2025-03-25 20:00:04.226713 INFO::Fitting model to feature number 756, F786
## 2025-03-25 20:00:04.231484 INFO::Fitting model to feature number 757, F787
## 2025-03-25 20:00:04.236167 INFO::Fitting model to feature number 758, F788
## 2025-03-25 20:00:04.240997 INFO::Fitting model to feature number 759, F789
## 2025-03-25 20:00:04.245769 INFO::Fitting model to feature number 760, F790
## 2025-03-25 20:00:04.250378 INFO::Fitting model to feature number 761, F791
## 2025-03-25 20:00:04.254986 INFO::Fitting model to feature number 762, F792
## 2025-03-25 20:00:04.259816 INFO::Fitting model to feature number 763, F793
## 2025-03-25 20:00:04.264457 INFO::Fitting model to feature number 764, F794
## 2025-03-25 20:00:04.269003 INFO::Fitting model to feature number 765, F795
## 2025-03-25 20:00:04.274804 INFO::Fitting model to feature number 766, F796
## 2025-03-25 20:00:04.28034 INFO::Fitting model to feature number 767, F797
## 2025-03-25 20:00:04.285207 INFO::Fitting model to feature number 768, F798
## 2025-03-25 20:00:04.290105 INFO::Fitting model to feature number 769, F799
## 2025-03-25 20:00:04.294828 INFO::Fitting model to feature number 770, F800
## 2025-03-25 20:00:04.299342 INFO::Fitting model to feature number 771, F801
## 2025-03-25 20:00:04.303967 INFO::Fitting model to feature number 772, F802
## 2025-03-25 20:00:04.308539 INFO::Fitting model to feature number 773, F803
## 2025-03-25 20:00:04.313026 INFO::Fitting model to feature number 774, F804
## 2025-03-25 20:00:04.317519 INFO::Fitting model to feature number 775, F805
## 2025-03-25 20:00:04.321961 INFO::Fitting model to feature number 776, F806
## 2025-03-25 20:00:04.326411 INFO::Fitting model to feature number 777, F808
## 2025-03-25 20:00:04.330813 INFO::Fitting model to feature number 778, F809
## 2025-03-25 20:00:04.335218 INFO::Fitting model to feature number 779, F810
## 2025-03-25 20:00:04.339608 INFO::Fitting model to feature number 780, F811
## 2025-03-25 20:00:04.344016 INFO::Fitting model to feature number 781, F812
## 2025-03-25 20:00:04.348347 INFO::Fitting model to feature number 782, F813
## 2025-03-25 20:00:04.352726 INFO::Fitting model to feature number 783, F814
## 2025-03-25 20:00:04.357193 INFO::Fitting model to feature number 784, F815
## 2025-03-25 20:00:04.363804 INFO::Fitting model to feature number 785, F816
## 2025-03-25 20:00:04.370625 INFO::Fitting model to feature number 786, F817
## 2025-03-25 20:00:04.377526 INFO::Fitting model to feature number 787, F818
## 2025-03-25 20:00:04.384532 INFO::Fitting model to feature number 788, F819
## 2025-03-25 20:00:04.391722 INFO::Fitting model to feature number 789, F820
## 2025-03-25 20:00:04.398711 INFO::Fitting model to feature number 790, F821
## 2025-03-25 20:00:04.405803 INFO::Fitting model to feature number 791, F822
## 2025-03-25 20:00:04.41311 INFO::Fitting model to feature number 792, F823
## 2025-03-25 20:00:04.420145 INFO::Fitting model to feature number 793, F824
## 2025-03-25 20:00:04.427531 INFO::Fitting model to feature number 794, F825
## 2025-03-25 20:00:04.435409 INFO::Fitting model to feature number 795, F826
## 2025-03-25 20:00:04.442849 INFO::Fitting model to feature number 796, F827
## 2025-03-25 20:00:04.448479 INFO::Fitting model to feature number 797, F828
## 2025-03-25 20:00:04.455441 INFO::Fitting model to feature number 798, F829
## 2025-03-25 20:00:04.461025 INFO::Fitting model to feature number 799, F830
## 2025-03-25 20:00:04.465736 INFO::Fitting model to feature number 800, F831
## 2025-03-25 20:00:04.472743 INFO::Fitting model to feature number 801, F832
## 2025-03-25 20:00:04.480044 INFO::Fitting model to feature number 802, F833
## 2025-03-25 20:00:04.48577 INFO::Fitting model to feature number 803, F834
## 2025-03-25 20:00:04.49054 INFO::Fitting model to feature number 804, F835
## 2025-03-25 20:00:04.49532 INFO::Fitting model to feature number 805, F836
## 2025-03-25 20:00:04.501342 INFO::Fitting model to feature number 806, F837
## 2025-03-25 20:00:04.508337 INFO::Fitting model to feature number 807, F838
## 2025-03-25 20:00:04.514927 INFO::Fitting model to feature number 808, F839
## 2025-03-25 20:00:04.519716 INFO::Fitting model to feature number 809, F840
## 2025-03-25 20:00:04.52438 INFO::Fitting model to feature number 810, F841
## 2025-03-25 20:00:04.52913 INFO::Fitting model to feature number 811, F842
## 2025-03-25 20:00:04.536163 INFO::Fitting model to feature number 812, F843
## 2025-03-25 20:00:04.543509 INFO::Fitting model to feature number 813, F844
## 2025-03-25 20:00:04.550817 INFO::Fitting model to feature number 814, F845
## 2025-03-25 20:00:04.55817 INFO::Fitting model to feature number 815, F846
## 2025-03-25 20:00:04.565828 INFO::Fitting model to feature number 816, F847
## 2025-03-25 20:00:04.57353 INFO::Fitting model to feature number 817, F848
## 2025-03-25 20:00:04.581148 INFO::Fitting model to feature number 818, F849
## 2025-03-25 20:00:04.588671 INFO::Fitting model to feature number 819, F850
## 2025-03-25 20:00:04.594421 INFO::Fitting model to feature number 820, F851
## 2025-03-25 20:00:04.599607 INFO::Fitting model to feature number 821, F852
## 2025-03-25 20:00:04.604271 INFO::Fitting model to feature number 822, F853
## 2025-03-25 20:00:04.609903 INFO::Fitting model to feature number 823, F854
## 2025-03-25 20:00:04.617278 INFO::Fitting model to feature number 824, F855
## 2025-03-25 20:00:04.624872 INFO::Fitting model to feature number 825, F856
## 2025-03-25 20:00:04.631068 INFO::Fitting model to feature number 826, F857
## 2025-03-25 20:00:04.637737 INFO::Fitting model to feature number 827, F858
## 2025-03-25 20:00:04.643442 INFO::Fitting model to feature number 828, F859
## 2025-03-25 20:00:04.648599 INFO::Fitting model to feature number 829, F860
## 2025-03-25 20:00:04.655723 INFO::Fitting model to feature number 830, F861
## 2025-03-25 20:00:04.661268 INFO::Fitting model to feature number 831, F862
## 2025-03-25 20:00:04.665954 INFO::Fitting model to feature number 832, F863
## 2025-03-25 20:00:04.671294 INFO::Fitting model to feature number 833, F864
## 2025-03-25 20:00:04.677249 INFO::Fitting model to feature number 834, F865
## 2025-03-25 20:00:04.682808 INFO::Fitting model to feature number 835, F866
## 2025-03-25 20:00:04.688334 INFO::Fitting model to feature number 836, F867
## 2025-03-25 20:00:04.69336 INFO::Fitting model to feature number 837, F868
## 2025-03-25 20:00:04.699854 INFO::Fitting model to feature number 838, F869
## 2025-03-25 20:00:04.707756 INFO::Fitting model to feature number 839, F870
## 2025-03-25 20:00:04.715691 INFO::Fitting model to feature number 840, F871
## 2025-03-25 20:00:04.721527 INFO::Fitting model to feature number 841, F872
## 2025-03-25 20:00:04.72677 INFO::Fitting model to feature number 842, F873
## 2025-03-25 20:00:04.731692 INFO::Fitting model to feature number 843, F874
## 2025-03-25 20:00:04.7375 INFO::Fitting model to feature number 844, F875
## 2025-03-25 20:00:04.742908 INFO::Fitting model to feature number 845, F876
## 2025-03-25 20:00:04.748064 INFO::Fitting model to feature number 846, F877
## 2025-03-25 20:00:04.755682 INFO::Fitting model to feature number 847, F878
## 2025-03-25 20:00:04.763236 INFO::Fitting model to feature number 848, F879
## 2025-03-25 20:00:04.770467 INFO::Fitting model to feature number 849, F880
## 2025-03-25 20:00:04.777035 INFO::Fitting model to feature number 850, F881
## 2025-03-25 20:00:04.783531 INFO::Fitting model to feature number 851, F882
## 2025-03-25 20:00:04.789083 INFO::Fitting model to feature number 852, F883
## 2025-03-25 20:00:04.79492 INFO::Fitting model to feature number 853, F884
## 2025-03-25 20:00:04.801629 INFO::Fitting model to feature number 854, F885
## 2025-03-25 20:00:04.80844 INFO::Fitting model to feature number 855, F886
## 2025-03-25 20:00:04.814411 INFO::Fitting model to feature number 856, F887
## 2025-03-25 20:00:04.82142 INFO::Fitting model to feature number 857, F888
## 2025-03-25 20:00:04.828956 INFO::Fitting model to feature number 858, F889
## 2025-03-25 20:00:04.836408 INFO::Fitting model to feature number 859, F890
## 2025-03-25 20:00:04.844134 INFO::Fitting model to feature number 860, F891
## 2025-03-25 20:00:04.852281 INFO::Fitting model to feature number 861, F892
## 2025-03-25 20:00:04.859987 INFO::Fitting model to feature number 862, F893
## 2025-03-25 20:00:04.867716 INFO::Fitting model to feature number 863, F894
## 2025-03-25 20:00:04.875126 INFO::Fitting model to feature number 864, F895
## 2025-03-25 20:00:04.882653 INFO::Fitting model to feature number 865, F896
## 2025-03-25 20:00:04.890314 INFO::Fitting model to feature number 866, F897
## 2025-03-25 20:00:04.897995 INFO::Fitting model to feature number 867, F898
## 2025-03-25 20:00:04.905589 INFO::Fitting model to feature number 868, F899
## 2025-03-25 20:00:04.913192 INFO::Fitting model to feature number 869, F900
## 2025-03-25 20:00:05.086678 INFO::Counting total values for each feature
## 2025-03-25 20:00:05.244343 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2025-03-25 20:00:05.52767 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2025-03-25 20:00:05.933209 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2025-03-25 20:00:06.257251 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2025-03-25 20:00:06.304054 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2025-03-25 20:00:06.347978 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2025-03-25 20:00:06.426495 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2025-03-25 20:00:06.471004 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2025-03-25 20:00:06.493515 INFO::Plotting associations from most to least significant, grouped by metadata
## 2025-03-25 20:00:06.495516 INFO::Plotting data for metadata number 1, diagnosis
## 2025-03-25 20:00:06.800631 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2025-03-25 20:00:07.264908 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2025-03-25 20:00:07.487902 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2025-03-25 20:00:07.740157 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2025-03-25 20:00:07.988533 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2025-03-25 20:00:08.211782 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2025-03-25 20:00:08.463992 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2025-03-25 20:00:08.64254 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2025-03-25 20:00:08.83322 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2025-03-25 20:00:09.353721 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2025-03-25 20:00:09.527935 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2025-03-25 20:00:09.712786 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2025-03-25 20:00:09.990095 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2025-03-25 20:00:10.242145 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2025-03-25 20:00:10.418241 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2025-03-25 20:00:10.610069 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2025-03-25 20:00:10.92551 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2025-03-25 20:00:11.201974 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2025-03-25 20:00:11.405166 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2025-03-25 20:00:11.583808 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2025-03-25 20:00:11.805698 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2025-03-25 20:00:12.044973 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2025-03-25 20:00:12.232094 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2025-03-25 20:00:12.400022 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2025-03-25 20:00:12.632716 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2025-03-25 20:00:12.902267 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2025-03-25 20:00:13.186099 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2025-03-25 20:00:13.404219 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2025-03-25 20:00:13.592441 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2025-03-25 20:00:13.859054 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2025-03-25 20:00:14.052029 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2025-03-25 20:00:14.239164 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2025-03-25 20:00:14.473901 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2025-03-25 20:00:14.649944 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2025-03-25 20:00:14.849118 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2025-03-25 20:00:15.107618 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2025-03-25 20:00:15.288785 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2025-03-25 20:00:15.45965 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2025-03-25 20:00:15.649267 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2025-03-25 20:00:15.830053 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2025-03-25 20:00:16.026531 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2025-03-25 20:00:16.211209 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2025-03-25 20:00:16.425581 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2025-03-25 20:00:16.637108 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2025-03-25 20:00:16.898821 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2025-03-25 20:00:17.175262 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2025-03-25 20:00:17.363643 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2025-03-25 20:00:17.604571 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2025-03-25 20:00:17.80438 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2025-03-25 20:00:18.082032 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2025-03-25 20:00:18.251872 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2025-03-25 20:00:18.43982 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2025-03-25 20:00:18.607655 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2025-03-25 20:00:18.791382 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2025-03-25 20:00:18.98291 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2025-03-25 20:00:19.15782 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2025-03-25 20:00:19.331427 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2025-03-25 20:00:19.617732 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2025-03-25 20:00:19.922025 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2025-03-25 20:00:20.197255 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2025-03-25 20:00:20.48216 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2025-03-25 20:00:20.764392 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2025-03-25 20:00:20.97963 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2025-03-25 20:00:21.151064 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2025-03-25 20:00:21.366379 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2025-03-25 20:00:21.553113 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2025-03-25 20:00:21.732834 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2025-03-25 20:00:21.937218 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2025-03-25 20:00:22.113328 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2025-03-25 20:00:22.370038 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2025-03-25 20:00:22.644628 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2025-03-25 20:00:22.889921 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2025-03-25 20:00:23.147353 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2025-03-25 20:00:23.377194 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2025-03-25 20:00:23.571752 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2025-03-25 20:00:23.842805 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2025-03-25 20:00:24.028163 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2025-03-25 20:00:24.210858 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2025-03-25 20:00:24.384912 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2025-03-25 20:00:24.568374 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2025-03-25 20:00:24.765137 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2025-03-25 20:00:24.965247 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2025-03-25 20:00:25.15373 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2025-03-25 20:00:25.332985 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2025-03-25 20:00:25.868873 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2025-03-25 20:00:26.061867 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2025-03-25 20:00:26.340993 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2025-03-25 20:00:26.545164 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2025-03-25 20:00:26.839387 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2025-03-25 20:00:27.132829 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2025-03-25 20:00:27.337549 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2025-03-25 20:00:27.549271 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2025-03-25 20:00:27.747246 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2025-03-25 20:00:28.007223 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2025-03-25 20:00:28.201426 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2025-03-25 20:00:28.386718 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2025-03-25 20:00:28.659599 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2025-03-25 20:00:28.892017 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2025-03-25 20:00:29.095376 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2025-03-25 20:00:29.338364 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2025-03-25 20:00:29.608287 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2025-03-25 20:00:29.830434 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2025-03-25 20:00:30.024597 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2025-03-25 20:00:30.213933 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2025-03-25 20:00:30.440368 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2025-03-25 20:00:30.622863 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2025-03-25 20:00:30.833178 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2025-03-25 20:00:31.100046 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2025-03-25 20:00:31.334368 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2025-03-25 20:00:31.507795 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2025-03-25 20:00:31.677566 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2025-03-25 20:00:31.865467 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2025-03-25 20:00:32.041146 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2025-03-25 20:00:32.210263 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2025-03-25 20:00:32.382383 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2025-03-25 20:00:32.559455 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2025-03-25 20:00:32.736626 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2025-03-25 20:00:32.934147 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2025-03-25 20:00:33.203214 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2025-03-25 20:00:33.417515 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2025-03-25 20:00:33.684686 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2025-03-25 20:00:33.920641 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2025-03-25 20:00:34.127571 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2025-03-25 20:00:34.303809 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2025-03-25 20:00:34.484641 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2025-03-25 20:00:34.665449 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2025-03-25 20:00:34.86 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2025-03-25 20:00:35.197969 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2025-03-25 20:00:35.450392 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2025-03-25 20:00:35.621813 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2025-03-25 20:00:35.794129 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2025-03-25 20:00:35.967216 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2025-03-25 20:00:36.17146 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2025-03-25 20:00:36.347184 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2025-03-25 20:00:36.521745 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2025-03-25 20:00:36.696882 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2025-03-25 20:00:36.88404 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2025-03-25 20:00:37.094097 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2025-03-25 20:00:37.287366 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2025-03-25 20:00:37.457207 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2025-03-25 20:00:37.645386 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2025-03-25 20:00:37.894989 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2025-03-25 20:00:38.077303 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2025-03-25 20:00:38.293763 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2025-03-25 20:00:38.526652 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2025-03-25 20:00:38.76139 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2025-03-25 20:00:38.980297 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2025-03-25 20:00:39.166433 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2025-03-25 20:00:39.37123 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2025-03-25 20:00:39.5767 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2025-03-25 20:00:39.803197 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2025-03-25 20:00:40.101869 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2025-03-25 20:00:40.321606 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2025-03-25 20:00:40.597215 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2025-03-25 20:00:40.838756 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2025-03-25 20:00:41.098078 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2025-03-25 20:00:41.345746 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2025-03-25 20:00:41.564533 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2025-03-25 20:00:41.827357 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2025-03-25 20:00:42.136679 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2025-03-25 20:00:42.340513 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2025-03-25 20:00:42.517909 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2025-03-25 20:00:42.740717 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2025-03-25 20:00:42.95397 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2025-03-25 20:00:43.210386 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2025-03-25 20:00:43.489242 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2025-03-25 20:00:43.754421 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2025-03-25 20:00:44.043825 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2025-03-25 20:00:44.31076 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2025-03-25 20:00:44.609082 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2025-03-25 20:00:44.866477 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2025-03-25 20:00:45.089291 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2025-03-25 20:00:45.286753 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2025-03-25 20:00:45.533789 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2025-03-25 20:00:45.706305 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2025-03-25 20:00:45.899325 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2025-03-25 20:00:46.073039 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2025-03-25 20:00:46.255806 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2025-03-25 20:00:46.425305 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2025-03-25 20:00:46.605083 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2025-03-25 20:00:46.89247 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2025-03-25 20:00:47.140348 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2025-03-25 20:00:47.39579 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2025-03-25 20:00:47.584248 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2025-03-25 20:00:47.75649 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2025-03-25 20:00:47.973078 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2025-03-25 20:00:48.155689 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2025-03-25 20:00:48.32549 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2025-03-25 20:00:48.53209 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2025-03-25 20:00:48.71128 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2025-03-25 20:00:48.904106 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2025-03-25 20:00:49.094828 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2025-03-25 20:00:49.313722 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2025-03-25 20:00:49.546038 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2025-03-25 20:00:49.733589 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2025-03-25 20:00:49.914667 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2025-03-25 20:00:50.110364 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2025-03-25 20:00:50.285789 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2025-03-25 20:00:50.462016 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2025-03-25 20:00:50.636906 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2025-03-25 20:00:50.816323 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2025-03-25 20:00:51.016368 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2025-03-25 20:00:51.188557 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2025-03-25 20:00:51.382374 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2025-03-25 20:00:51.55775 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2025-03-25 20:00:51.745192 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2025-03-25 20:00:52.058882 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2025-03-25 20:00:52.229926 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2025-03-25 20:00:52.399147 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2025-03-25 20:00:52.570425 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2025-03-25 20:00:52.755366 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2025-03-25 20:00:53.008325 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2025-03-25 20:00:53.273002 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2025-03-25 20:00:53.452405 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2025-03-25 20:00:53.638511 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2025-03-25 20:00:53.888012 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2025-03-25 20:00:54.160095 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2025-03-25 20:00:54.348356 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2025-03-25 20:00:54.530097 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2025-03-25 20:00:54.707264 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2025-03-25 20:00:54.986806 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2025-03-25 20:00:55.254651 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2025-03-25 20:00:55.458743 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2025-03-25 20:00:55.644261 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2025-03-25 20:00:55.884899 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2025-03-25 20:00:56.072126 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2025-03-25 20:00:56.312123 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2025-03-25 20:00:56.636582 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2025-03-25 20:00:56.898422 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2025-03-25 20:00:57.109202 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2025-03-25 20:00:57.336407 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2025-03-25 20:00:57.554129 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2025-03-25 20:00:57.808303 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2025-03-25 20:00:58.030663 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2025-03-25 20:00:58.27096 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2025-03-25 20:00:58.469895 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2025-03-25 20:00:58.639818 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2025-03-25 20:00:59.710507 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2025-03-25 20:00:59.911094 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2025-03-25 20:01:00.118629 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2025-03-25 20:01:00.329186 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2025-03-25 20:01:00.529708 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2025-03-25 20:01:00.814895 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2025-03-25 20:01:01.079385 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2025-03-25 20:01:01.345734 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2025-03-25 20:01:01.614514 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2025-03-25 20:01:01.884829 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2025-03-25 20:01:02.059367 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2025-03-25 20:01:02.237533 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2025-03-25 20:01:02.405442 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2025-03-25 20:01:02.586086 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2025-03-25 20:01:02.804941 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2025-03-25 20:01:03.035856 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2025-03-25 20:01:03.280347 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2025-03-25 20:01:03.509558 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2025-03-25 20:01:03.747674 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2025-03-25 20:01:03.993162 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2025-03-25 20:01:04.183799 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2025-03-25 20:01:04.374226 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2025-03-25 20:01:04.577345 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2025-03-25 20:01:04.760485 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2025-03-25 20:01:04.93714 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2025-03-25 20:01:05.105852 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2025-03-25 20:01:05.35576 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2025-03-25 20:01:05.61588 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2025-03-25 20:01:05.786915 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2025-03-25 20:01:05.98191 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2025-03-25 20:01:06.148752 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2025-03-25 20:01:06.338161 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2025-03-25 20:01:06.521716 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2025-03-25 20:01:06.68903 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2025-03-25 20:01:06.854482 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2025-03-25 20:01:07.028308 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2025-03-25 20:01:07.202492 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2025-03-25 20:01:07.495974 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2025-03-25 20:01:07.781511 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2025-03-25 20:01:07.954199 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2025-03-25 20:01:08.127578 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2025-03-25 20:01:08.346185 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2025-03-25 20:01:08.52281 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2025-03-25 20:01:08.713577 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2025-03-25 20:01:08.966389 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2025-03-25 20:01:09.178358 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2025-03-25 20:01:09.377132 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2025-03-25 20:01:09.578582 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2025-03-25 20:01:09.780133 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2025-03-25 20:01:09.941747 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2025-03-25 20:01:10.194983 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2025-03-25 20:01:10.407031 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2025-03-25 20:01:10.579873 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2025-03-25 20:01:10.767583 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2025-03-25 20:01:10.957924 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2025-03-25 20:01:11.134012 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2025-03-25 20:01:11.36246 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2025-03-25 20:01:11.60086 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2025-03-25 20:01:11.799833 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2025-03-25 20:01:12.070682 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2025-03-25 20:01:12.239521 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2025-03-25 20:01:12.405524 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2025-03-25 20:01:12.608882 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2025-03-25 20:01:12.794229 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2025-03-25 20:01:12.998899 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2025-03-25 20:01:13.16732 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2025-03-25 20:01:13.335569 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2025-03-25 20:01:13.53208 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2025-03-25 20:01:13.744312 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2025-03-25 20:01:13.956231 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2025-03-25 20:01:14.196943 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2025-03-25 20:01:14.40469 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2025-03-25 20:01:14.664083 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2025-03-25 20:01:14.902837 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2025-03-25 20:01:15.101694 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2025-03-25 20:01:15.353034 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2025-03-25 20:01:15.53799 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2025-03-25 20:01:15.724887 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2025-03-25 20:01:15.929489 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2025-03-25 20:01:16.130063 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2025-03-25 20:01:16.315773 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2025-03-25 20:01:16.556347 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2025-03-25 20:01:16.720097 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2025-03-25 20:01:16.995247 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2025-03-25 20:01:17.293809 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2025-03-25 20:01:17.483073 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2025-03-25 20:01:17.657462 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2025-03-25 20:01:17.857075 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2025-03-25 20:01:18.071384 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2025-03-25 20:01:18.291632 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2025-03-25 20:01:18.584885 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2025-03-25 20:01:18.846097 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2025-03-25 20:01:19.039434 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2025-03-25 20:01:19.206835 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2025-03-25 20:01:19.386644 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2025-03-25 20:01:19.573818 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2025-03-25 20:01:19.750258 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2025-03-25 20:01:19.943151 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2025-03-25 20:01:20.131156 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2025-03-25 20:01:20.302384 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2025-03-25 20:01:20.482296 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2025-03-25 20:01:20.716857 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2025-03-25 20:01:20.885919 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2025-03-25 20:01:21.061656 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2025-03-25 20:01:21.235241 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2025-03-25 20:01:21.429419 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2025-03-25 20:01:21.60828 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2025-03-25 20:01:21.789398 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2025-03-25 20:01:21.959723 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2025-03-25 20:01:22.137112 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2025-03-25 20:01:22.414258 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2025-03-25 20:01:22.626782 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2025-03-25 20:01:22.795453 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2025-03-25 20:01:22.988745 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2025-03-25 20:01:23.207277 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2025-03-25 20:01:23.432932 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2025-03-25 20:01:23.66022 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2025-03-25 20:01:23.859393 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2025-03-25 20:01:24.06701 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2025-03-25 20:01:24.325524 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2025-03-25 20:01:24.497302 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2025-03-25 20:01:24.69141 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2025-03-25 20:01:24.907259 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2025-03-25 20:01:25.085278 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2025-03-25 20:01:25.257788 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2025-03-25 20:01:25.433048 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2025-03-25 20:01:25.63567 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2025-03-25 20:01:25.895502 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2025-03-25 20:01:26.166715 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2025-03-25 20:01:26.435313 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2025-03-25 20:01:26.625757 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2025-03-25 20:01:26.831088 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2025-03-25 20:01:27.066982 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2025-03-25 20:01:27.273433 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2025-03-25 20:01:27.466016 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2025-03-25 20:01:27.643784 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2025-03-25 20:01:27.817681 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2025-03-25 20:01:28.016301 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2025-03-25 20:01:28.226222 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2025-03-25 20:01:28.435464 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2025-03-25 20:01:28.619856 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2025-03-25 20:01:28.859277 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2025-03-25 20:01:29.055696 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2025-03-25 20:01:29.304568 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2025-03-25 20:01:29.5642 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2025-03-25 20:01:29.830209 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2025-03-25 20:01:30.049515 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2025-03-25 20:01:30.24676 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2025-03-25 20:01:30.513389 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2025-03-25 20:01:30.78796 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2025-03-25 20:01:31.000058 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2025-03-25 20:01:31.223365 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2025-03-25 20:01:31.411156 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2025-03-25 20:01:31.599862 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2025-03-25 20:01:31.773243 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2025-03-25 20:01:31.94163 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2025-03-25 20:01:32.108545 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2025-03-25 20:01:32.274885 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2025-03-25 20:01:32.503496 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2025-03-25 20:01:32.781212 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2025-03-25 20:01:32.988706 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2025-03-25 20:01:33.21461 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2025-03-25 20:01:33.456912 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2025-03-25 20:01:33.701097 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2025-03-25 20:01:33.981121 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2025-03-25 20:01:34.178612 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2025-03-25 20:01:34.348486 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2025-03-25 20:01:34.517016 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2025-03-25 20:01:34.789206 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2025-03-25 20:01:35.058457 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2025-03-25 20:01:35.230916 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2025-03-25 20:01:35.405154 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2025-03-25 20:01:35.588034 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2025-03-25 20:01:35.861783 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2025-03-25 20:01:36.155146 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2025-03-25 20:01:36.355958 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2025-03-25 20:01:36.525873 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2025-03-25 20:01:36.695286 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2025-03-25 20:01:36.866785 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2025-03-25 20:01:37.318239 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2025-03-25 20:01:37.498584 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2025-03-25 20:01:37.714522 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2025-03-25 20:01:37.895561 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2025-03-25 20:01:38.131366 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2025-03-25 20:01:38.299939 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2025-03-25 20:01:38.491222 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2025-03-25 20:01:38.65498 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2025-03-25 20:01:38.835905 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2025-03-25 20:01:39.00769 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2025-03-25 20:01:39.177191 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2025-03-25 20:01:39.375084 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2025-03-25 20:01:39.558273 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2025-03-25 20:01:39.763829 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2025-03-25 20:01:39.948385 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2025-03-25 20:01:40.126627 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2025-03-25 20:01:40.382731 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2025-03-25 20:01:40.597797 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2025-03-25 20:01:40.845074 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2025-03-25 20:01:41.057461 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2025-03-25 20:01:41.28659 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2025-03-25 20:01:41.535538 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2025-03-25 20:01:41.750317 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2025-03-25 20:01:42.003764 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2025-03-25 20:01:42.259688 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2025-03-25 20:01:42.46433 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2025-03-25 20:01:42.678828 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2025-03-25 20:01:42.882133 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2025-03-25 20:01:43.052384 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2025-03-25 20:01:43.224377 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2025-03-25 20:01:43.393012 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2025-03-25 20:01:43.58512 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2025-03-25 20:01:43.824873 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2025-03-25 20:01:44.011133 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2025-03-25 20:01:44.25738 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2025-03-25 20:01:44.496765 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2025-03-25 20:01:44.742002 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2025-03-25 20:01:44.935763 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2025-03-25 20:01:45.154556 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2025-03-25 20:01:45.38625 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2025-03-25 20:01:45.605883 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2025-03-25 20:01:45.775354 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2025-03-25 20:01:46.040625 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2025-03-25 20:01:46.212956 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2025-03-25 20:01:46.383303 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2025-03-25 20:01:46.556333 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2025-03-25 20:01:46.781789 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2025-03-25 20:01:47.062612 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2025-03-25 20:01:47.344145 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2025-03-25 20:01:47.624623 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2025-03-25 20:01:47.819855 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2025-03-25 20:01:48.122915 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2025-03-25 20:01:48.438473 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2025-03-25 20:01:48.68934 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2025-03-25 20:01:48.903985 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2025-03-25 20:01:49.185435 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2025-03-25 20:01:49.451668 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2025-03-25 20:01:49.708766 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2025-03-25 20:01:49.964877 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2025-03-25 20:01:50.243482 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2025-03-25 20:01:50.426013 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2025-03-25 20:01:50.606555 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2025-03-25 20:01:50.78223 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2025-03-25 20:01:51.002407 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2025-03-25 20:01:51.180323 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2025-03-25 20:01:51.363007 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2025-03-25 20:01:51.539308 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2025-03-25 20:01:51.722657 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2025-03-25 20:01:51.939905 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2025-03-25 20:01:52.141814 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2025-03-25 20:01:52.322353 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2025-03-25 20:01:52.532314 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2025-03-25 20:01:52.816613 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2025-03-25 20:01:53.028858 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2025-03-25 20:01:53.236041 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2025-03-25 20:01:53.467519 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2025-03-25 20:01:53.728683 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2025-03-25 20:01:53.9775 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2025-03-25 20:01:54.176406 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2025-03-25 20:01:54.427473 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2025-03-25 20:01:54.655688 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2025-03-25 20:01:54.830006 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2025-03-25 20:01:55.009467 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2025-03-25 20:01:55.181855 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2025-03-25 20:01:55.489238 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2025-03-25 20:01:55.764409 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2025-03-25 20:01:56.037659 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2025-03-25 20:01:56.32351 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2025-03-25 20:01:56.616944 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2025-03-25 20:01:56.952435 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2025-03-25 20:01:57.23243 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2025-03-25 20:01:57.510682 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2025-03-25 20:01:57.833181 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2025-03-25 20:01:58.089173 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2025-03-25 20:01:58.396292 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2025-03-25 20:01:58.678194 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2025-03-25 20:01:58.973623 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2025-03-25 20:01:59.211524 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2025-03-25 20:01:59.457603 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2025-03-25 20:01:59.727625 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2025-03-25 20:02:00.03377 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2025-03-25 20:02:00.304426 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2025-03-25 20:02:00.516123 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2025-03-25 20:02:00.759061 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2025-03-25 20:02:01.016677 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2025-03-25 20:02:01.23296 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2025-03-25 20:02:01.523215 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2025-03-25 20:02:01.740879 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2025-03-25 20:02:01.981342 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2025-03-25 20:02:02.255712 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2025-03-25 20:02:02.607806 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2025-03-25 20:02:02.837906 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2025-03-25 20:02:03.050108 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2025-03-25 20:02:03.266046 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2025-03-25 20:02:03.457089 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2025-03-25 20:02:03.721856 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2025-03-25 20:02:03.925473 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2025-03-25 20:02:04.167284 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2025-03-25 20:02:04.453907 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2025-03-25 20:02:04.704827 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2025-03-25 20:02:04.937918 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2025-03-25 20:02:05.246265 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2025-03-25 20:02:05.458181 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2025-03-25 20:02:05.64619 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2025-03-25 20:02:05.824149 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2025-03-25 20:02:06.09232 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2025-03-25 20:02:06.37608 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2025-03-25 20:02:06.592547 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2025-03-25 20:02:06.882337 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2025-03-25 20:02:07.113908 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2025-03-25 20:02:07.321261 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2025-03-25 20:02:07.60687 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2025-03-25 20:02:07.865108 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2025-03-25 20:02:08.122664 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2025-03-25 20:02:08.378636 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2025-03-25 20:02:08.658285 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2025-03-25 20:02:08.961915 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2025-03-25 20:02:09.274215 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2025-03-25 20:02:09.563827 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2025-03-25 20:02:09.786959 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2025-03-25 20:02:09.979098 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2025-03-25 20:02:12.973166 INFO::Plotting data for metadata number 2, antibiotics
## 2025-03-25 20:02:12.977635 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2025-03-25 20:02:13.237383 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2025-03-25 20:02:13.673865 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2025-03-25 20:02:14.002719 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2025-03-25 20:02:14.28988 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2025-03-25 20:02:14.591123 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2025-03-25 20:02:14.908468 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2025-03-25 20:02:15.193663 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2025-03-25 20:02:15.474641 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2025-03-25 20:02:15.770743 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2025-03-25 20:02:16.053385 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2025-03-25 20:02:16.361033 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2025-03-25 20:02:16.595514 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2025-03-25 20:02:16.875994 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2025-03-25 20:02:17.131744 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2025-03-25 20:02:17.393598 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2025-03-25 20:02:17.725644 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2025-03-25 20:02:18.085992 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2025-03-25 20:02:18.392175 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2025-03-25 20:02:18.619324 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2025-03-25 20:02:18.910345 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2025-03-25 20:02:19.13651 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2025-03-25 20:02:19.421156 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2025-03-25 20:02:19.644516 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2025-03-25 20:02:19.972302 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2025-03-25 20:02:20.32583 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2025-03-25 20:02:20.633299 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2025-03-25 20:02:20.958699 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2025-03-25 20:02:21.261343 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2025-03-25 20:02:21.547293 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2025-03-25 20:02:21.793858 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2025-03-25 20:02:22.119527 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2025-03-25 20:02:22.359617 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2025-03-25 20:02:22.609254 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2025-03-25 20:02:22.829759 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2025-03-25 20:02:23.142119 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2025-03-25 20:02:23.365788 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2025-03-25 20:02:23.599927 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2025-03-25 20:02:23.819976 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2025-03-25 20:02:24.100567 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2025-03-25 20:02:24.324092 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2025-03-25 20:02:24.559029 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2025-03-25 20:02:24.822343 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2025-03-25 20:02:25.082192 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2025-03-25 20:02:25.298408 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2025-03-25 20:02:25.51646 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2025-03-25 20:02:25.77471 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2025-03-25 20:02:26.108684 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2025-03-25 20:02:26.359808 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2025-03-25 20:02:26.588599 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2025-03-25 20:02:26.88536 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2025-03-25 20:02:27.206121 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2025-03-25 20:02:27.445153 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2025-03-25 20:02:27.756012 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2025-03-25 20:02:28.090411 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2025-03-25 20:02:28.380058 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2025-03-25 20:02:28.655527 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2025-03-25 20:02:28.916247 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2025-03-25 20:02:29.225855 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2025-03-25 20:02:29.51983 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2025-03-25 20:02:29.811917 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2025-03-25 20:02:30.133957 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2025-03-25 20:02:30.421673 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2025-03-25 20:02:30.721818 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2025-03-25 20:02:30.988096 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2025-03-25 20:02:31.319779 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2025-03-25 20:02:31.59825 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2025-03-25 20:02:31.855026 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2025-03-25 20:02:32.166593 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2025-03-25 20:02:32.456731 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2025-03-25 20:02:32.728817 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2025-03-25 20:02:33.058529 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2025-03-25 20:02:33.314181 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2025-03-25 20:02:33.621746 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2025-03-25 20:02:33.922086 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2025-03-25 20:02:34.436695 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2025-03-25 20:02:34.768813 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2025-03-25 20:02:35.056134 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2025-03-25 20:02:35.343262 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2025-03-25 20:02:35.649793 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2025-03-25 20:02:35.990133 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2025-03-25 20:02:36.278484 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2025-03-25 20:02:36.601666 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2025-03-25 20:02:37.108904 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2025-03-25 20:02:37.429408 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2025-03-25 20:02:37.776752 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2025-03-25 20:02:38.035788 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2025-03-25 20:02:38.322064 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2025-03-25 20:02:38.636805 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2025-03-25 20:02:38.885068 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2025-03-25 20:02:39.114417 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2025-03-25 20:02:39.306937 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2025-03-25 20:02:39.502907 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2025-03-25 20:02:39.761005 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2025-03-25 20:02:39.98506 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2025-03-25 20:02:40.183032 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2025-03-25 20:02:40.384658 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2025-03-25 20:02:40.584163 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2025-03-25 20:02:40.852008 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2025-03-25 20:02:41.132779 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2025-03-25 20:02:41.344648 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2025-03-25 20:02:41.543577 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2025-03-25 20:02:41.742083 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2025-03-25 20:02:41.947813 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2025-03-25 20:02:42.352808 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2025-03-25 20:02:42.601409 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2025-03-25 20:02:42.816559 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2025-03-25 20:02:43.10725 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2025-03-25 20:02:43.341452 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2025-03-25 20:02:43.568385 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2025-03-25 20:02:43.766888 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2025-03-25 20:02:43.963385 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2025-03-25 20:02:44.190639 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2025-03-25 20:02:44.494165 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2025-03-25 20:02:44.809134 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2025-03-25 20:02:45.127124 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2025-03-25 20:02:45.446131 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2025-03-25 20:02:45.707636 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2025-03-25 20:02:45.957913 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2025-03-25 20:02:46.327082 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2025-03-25 20:02:46.547488 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2025-03-25 20:02:46.757867 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2025-03-25 20:02:46.94211 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2025-03-25 20:02:47.165136 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2025-03-25 20:02:47.470622 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2025-03-25 20:02:47.670689 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2025-03-25 20:02:47.946495 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2025-03-25 20:02:48.258476 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2025-03-25 20:02:48.442345 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2025-03-25 20:02:48.666692 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2025-03-25 20:02:48.857251 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2025-03-25 20:02:49.134144 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2025-03-25 20:02:49.420924 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2025-03-25 20:02:49.738351 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2025-03-25 20:02:49.981335 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2025-03-25 20:02:50.219492 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2025-03-25 20:02:50.466843 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2025-03-25 20:02:50.716473 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2025-03-25 20:02:50.975758 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2025-03-25 20:02:51.299864 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2025-03-25 20:02:51.504556 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2025-03-25 20:02:51.692895 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2025-03-25 20:02:51.874273 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2025-03-25 20:02:52.211072 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2025-03-25 20:02:52.467317 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2025-03-25 20:02:52.691397 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2025-03-25 20:02:52.903079 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2025-03-25 20:02:53.145336 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2025-03-25 20:02:53.445837 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2025-03-25 20:02:53.673599 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2025-03-25 20:02:53.86989 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2025-03-25 20:02:54.127742 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2025-03-25 20:02:54.436594 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2025-03-25 20:02:54.803303 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2025-03-25 20:02:55.127092 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2025-03-25 20:02:55.396341 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2025-03-25 20:02:55.578165 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2025-03-25 20:02:55.784105 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2025-03-25 20:02:56.086523 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2025-03-25 20:02:56.330743 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2025-03-25 20:02:56.53229 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2025-03-25 20:02:56.71438 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2025-03-25 20:02:56.919969 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2025-03-25 20:02:57.152232 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2025-03-25 20:02:57.341481 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2025-03-25 20:02:57.539383 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2025-03-25 20:02:57.720036 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2025-03-25 20:02:57.977761 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2025-03-25 20:02:58.293076 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2025-03-25 20:02:58.502165 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2025-03-25 20:02:58.808774 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2025-03-25 20:02:59.116174 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2025-03-25 20:02:59.36924 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2025-03-25 20:02:59.558418 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2025-03-25 20:02:59.747682 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2025-03-25 20:02:59.946306 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2025-03-25 20:03:00.125926 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2025-03-25 20:03:00.351636 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2025-03-25 20:03:00.54432 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2025-03-25 20:03:00.739496 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2025-03-25 20:03:00.942424 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2025-03-25 20:03:01.225891 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2025-03-25 20:03:01.566475 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2025-03-25 20:03:01.804216 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2025-03-25 20:03:02.002002 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2025-03-25 20:03:02.184122 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2025-03-25 20:03:02.37088 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2025-03-25 20:03:02.596767 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2025-03-25 20:03:02.785172 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2025-03-25 20:03:02.993455 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2025-03-25 20:03:03.202554 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2025-03-25 20:03:03.43824 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2025-03-25 20:03:03.651062 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2025-03-25 20:03:03.884784 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2025-03-25 20:03:04.085186 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2025-03-25 20:03:04.338015 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2025-03-25 20:03:04.576833 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2025-03-25 20:03:04.791333 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2025-03-25 20:03:05.029048 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2025-03-25 20:03:05.232766 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2025-03-25 20:03:05.501917 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2025-03-25 20:03:05.821672 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2025-03-25 20:03:06.088304 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2025-03-25 20:03:06.381797 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2025-03-25 20:03:06.599003 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2025-03-25 20:03:06.952689 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2025-03-25 20:03:07.286758 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2025-03-25 20:03:07.531533 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2025-03-25 20:03:07.806827 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2025-03-25 20:03:08.060315 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2025-03-25 20:03:08.315306 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2025-03-25 20:03:08.592225 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2025-03-25 20:03:08.829344 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2025-03-25 20:03:09.100273 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2025-03-25 20:03:09.331378 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2025-03-25 20:03:09.581088 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2025-03-25 20:03:09.843481 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2025-03-25 20:03:10.15593 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2025-03-25 20:03:10.416315 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2025-03-25 20:03:10.615033 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2025-03-25 20:03:10.892418 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2025-03-25 20:03:11.206934 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2025-03-25 20:03:11.45868 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2025-03-25 20:03:11.712717 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2025-03-25 20:03:12.031308 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2025-03-25 20:03:12.339753 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2025-03-25 20:03:12.603959 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2025-03-25 20:03:12.837603 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2025-03-25 20:03:13.142212 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2025-03-25 20:03:13.471268 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2025-03-25 20:03:13.772955 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2025-03-25 20:03:14.062766 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2025-03-25 20:03:14.300602 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2025-03-25 20:03:14.503222 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2025-03-25 20:03:14.717504 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2025-03-25 20:03:14.963482 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2025-03-25 20:03:15.257355 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2025-03-25 20:03:15.526891 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2025-03-25 20:03:15.825021 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2025-03-25 20:03:16.092528 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2025-03-25 20:03:16.320113 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2025-03-25 20:03:16.561036 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2025-03-25 20:03:16.959288 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2025-03-25 20:03:17.219577 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2025-03-25 20:03:17.438855 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2025-03-25 20:03:17.716846 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2025-03-25 20:03:17.953169 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2025-03-25 20:03:18.171174 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2025-03-25 20:03:18.37495 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2025-03-25 20:03:18.569998 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2025-03-25 20:03:18.820395 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2025-03-25 20:03:19.065765 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2025-03-25 20:03:19.275316 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2025-03-25 20:03:19.590632 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2025-03-25 20:03:19.818693 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2025-03-25 20:03:20.13911 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2025-03-25 20:03:20.370414 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2025-03-25 20:03:20.59903 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2025-03-25 20:03:20.806582 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2025-03-25 20:03:21.08529 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2025-03-25 20:03:21.316429 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2025-03-25 20:03:21.620741 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2025-03-25 20:03:21.926562 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2025-03-25 20:03:22.243815 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2025-03-25 20:03:22.524721 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2025-03-25 20:03:22.752592 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2025-03-25 20:03:22.964136 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2025-03-25 20:03:23.191802 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2025-03-25 20:03:23.502801 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2025-03-25 20:03:23.863372 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2025-03-25 20:03:24.094638 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2025-03-25 20:03:24.403084 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2025-03-25 20:03:24.700081 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2025-03-25 20:03:24.955854 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2025-03-25 20:03:25.234925 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2025-03-25 20:03:25.445835 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2025-03-25 20:03:25.647587 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2025-03-25 20:03:25.842683 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2025-03-25 20:03:26.026687 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2025-03-25 20:03:26.251175 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2025-03-25 20:03:26.439969 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2025-03-25 20:03:26.629879 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2025-03-25 20:03:26.870143 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2025-03-25 20:03:27.203817 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2025-03-25 20:03:27.479726 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2025-03-25 20:03:27.689819 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2025-03-25 20:03:27.886834 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2025-03-25 20:03:28.093974 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2025-03-25 20:03:28.36012 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2025-03-25 20:03:28.655826 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2025-03-25 20:03:28.947438 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2025-03-25 20:03:29.224413 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2025-03-25 20:03:29.488656 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2025-03-25 20:03:29.713424 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2025-03-25 20:03:29.917145 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2025-03-25 20:03:30.121108 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2025-03-25 20:03:30.32323 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2025-03-25 20:03:30.516007 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2025-03-25 20:03:30.753932 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2025-03-25 20:03:30.954996 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2025-03-25 20:03:31.154155 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2025-03-25 20:03:31.347539 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2025-03-25 20:03:31.576535 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2025-03-25 20:03:31.911815 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2025-03-25 20:03:32.230002 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2025-03-25 20:03:32.428457 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2025-03-25 20:03:32.61154 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2025-03-25 20:03:33.554255 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2025-03-25 20:03:33.72768 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2025-03-25 20:03:33.900296 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2025-03-25 20:03:34.079789 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2025-03-25 20:03:34.342216 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2025-03-25 20:03:34.53736 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2025-03-25 20:03:34.715685 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2025-03-25 20:03:34.892065 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2025-03-25 20:03:35.078418 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2025-03-25 20:03:35.266335 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2025-03-25 20:03:35.461201 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2025-03-25 20:03:35.644505 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2025-03-25 20:03:35.840343 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2025-03-25 20:03:36.078073 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2025-03-25 20:03:36.267945 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2025-03-25 20:03:36.495618 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2025-03-25 20:03:36.753974 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2025-03-25 20:03:37.008404 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2025-03-25 20:03:37.207455 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2025-03-25 20:03:37.391096 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2025-03-25 20:03:37.592661 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2025-03-25 20:03:37.776908 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2025-03-25 20:03:37.964089 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2025-03-25 20:03:38.192349 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2025-03-25 20:03:38.497201 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2025-03-25 20:03:38.823141 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2025-03-25 20:03:39.110614 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2025-03-25 20:03:39.372321 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2025-03-25 20:03:39.663229 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2025-03-25 20:03:39.96484 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2025-03-25 20:03:40.165269 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2025-03-25 20:03:40.374423 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2025-03-25 20:03:40.665067 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2025-03-25 20:03:40.878533 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2025-03-25 20:03:41.076133 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2025-03-25 20:03:41.328759 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2025-03-25 20:03:41.552632 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2025-03-25 20:03:41.79491 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2025-03-25 20:03:42.020716 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2025-03-25 20:03:42.235573 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2025-03-25 20:03:42.426047 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2025-03-25 20:03:42.599583 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2025-03-25 20:03:42.800992 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2025-03-25 20:03:42.982503 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2025-03-25 20:03:43.163518 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2025-03-25 20:03:43.367191 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2025-03-25 20:03:43.573828 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2025-03-25 20:03:43.751916 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2025-03-25 20:03:43.951929 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2025-03-25 20:03:44.238811 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2025-03-25 20:03:44.542215 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2025-03-25 20:03:44.843777 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2025-03-25 20:03:45.150939 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2025-03-25 20:03:45.443235 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2025-03-25 20:03:45.639571 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2025-03-25 20:03:45.865518 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2025-03-25 20:03:46.056657 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2025-03-25 20:03:46.232135 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2025-03-25 20:03:46.412464 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2025-03-25 20:03:46.596588 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2025-03-25 20:03:46.795086 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2025-03-25 20:03:46.989627 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2025-03-25 20:03:47.200769 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2025-03-25 20:03:47.379995 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2025-03-25 20:03:47.558012 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2025-03-25 20:03:47.748756 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2025-03-25 20:03:47.935146 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2025-03-25 20:03:48.114915 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2025-03-25 20:03:48.297235 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2025-03-25 20:03:48.474914 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2025-03-25 20:03:48.66341 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2025-03-25 20:03:48.836408 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2025-03-25 20:03:49.012785 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2025-03-25 20:03:49.191296 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2025-03-25 20:03:49.369817 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2025-03-25 20:03:49.556374 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2025-03-25 20:03:49.731654 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2025-03-25 20:03:49.913535 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2025-03-25 20:03:50.0963 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2025-03-25 20:03:50.288002 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2025-03-25 20:03:50.464797 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2025-03-25 20:03:50.645084 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2025-03-25 20:03:50.824899 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2025-03-25 20:03:51.04439 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2025-03-25 20:03:51.318018 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2025-03-25 20:03:51.547991 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2025-03-25 20:03:51.771077 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2025-03-25 20:03:52.015687 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2025-03-25 20:03:52.238069 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2025-03-25 20:03:52.457187 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2025-03-25 20:03:52.676674 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2025-03-25 20:03:52.918833 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2025-03-25 20:03:53.22318 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2025-03-25 20:03:53.422343 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2025-03-25 20:03:53.691927 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2025-03-25 20:03:53.908175 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2025-03-25 20:03:54.089378 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2025-03-25 20:03:54.308864 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2025-03-25 20:03:54.510494 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2025-03-25 20:03:54.700571 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2025-03-25 20:03:54.882181 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2025-03-25 20:03:55.14938 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2025-03-25 20:03:55.345211 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2025-03-25 20:03:55.689607 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2025-03-25 20:03:55.894399 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2025-03-25 20:03:56.08419 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2025-03-25 20:03:56.308057 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2025-03-25 20:03:56.547675 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2025-03-25 20:03:56.800509 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2025-03-25 20:03:57.133673 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2025-03-25 20:03:57.357237 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2025-03-25 20:03:57.617108 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2025-03-25 20:03:57.920385 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2025-03-25 20:03:58.200378 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2025-03-25 20:03:58.490314 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2025-03-25 20:03:58.700539 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2025-03-25 20:03:58.960288 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2025-03-25 20:03:59.141186 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2025-03-25 20:03:59.330606 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2025-03-25 20:03:59.538681 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2025-03-25 20:03:59.722422 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2025-03-25 20:03:59.927324 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2025-03-25 20:04:00.213666 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2025-03-25 20:04:00.432801 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2025-03-25 20:04:00.664243 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2025-03-25 20:04:00.915536 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2025-03-25 20:04:01.156653 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2025-03-25 20:04:01.383688 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2025-03-25 20:04:01.593425 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2025-03-25 20:04:01.811986 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2025-03-25 20:04:04.772445 INFO::Plotting data for metadata number 3, age
## 2025-03-25 20:04:04.775249 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:05.056714 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:05.40198 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:05.677885 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:05.897629 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:06.237812 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:06.542598 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:06.731463 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:06.964942 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:07.14128 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:07.317724 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:07.508524 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:07.792012 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:08.069216 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:08.35835 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:08.569019 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:08.783927 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:09.006037 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:09.207193 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:09.4008 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:09.618064 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:09.838445 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:10.05168 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:10.248193 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:10.506534 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:10.682512 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:10.909833 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:11.104778 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:11.304852 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:11.58268 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:11.887005 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:12.070344 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:12.274494 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:12.519105 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:12.770879 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:13.033075 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:13.284992 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:13.540202 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:13.781912 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:14.017348 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:14.232522 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:14.464376 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:14.686761 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:14.934693 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:15.135892 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:15.329779 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:15.55511 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:15.799711 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:16.028775 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:16.292645 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:16.553915 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:16.786296 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:17.049656 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:17.242729 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:17.425341 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:17.63894 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:17.938772 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:18.237807 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:18.433979 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:18.635701 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:18.836207 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:19.158222 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:19.366652 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:19.569789 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:19.833556 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:20.051701 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:20.252551 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:20.505395 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:20.786711 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:20.991647 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:21.316289 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:21.62437 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:21.892309 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:22.149494 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:22.501472 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:22.691897 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:23.030196 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:23.352982 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:23.665779 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:23.951017 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:24.153347 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:24.363042 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:24.645724 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:24.994466 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:25.342935 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:25.655324 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:25.941238 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:26.284214 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:26.587125 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:26.813607 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:27.018041 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:27.350957 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:27.582144 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:27.785487 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:27.993315 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:28.172685 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:28.371805 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:28.618763 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:28.888111 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:29.142119 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:29.347436 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:29.604351 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:29.851299 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:30.040441 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:30.25269 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:30.472572 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:30.680297 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:30.976602 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:31.309873 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:31.593889 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:31.920972 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:32.208743 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:32.476686 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:32.690194 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:32.950787 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:33.302593 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:33.562869 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:33.822855 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:34.113782 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:34.483217 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:34.769496 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:35.023699 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:35.299577 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:35.709264 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:35.927164 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:36.228682 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:36.451127 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:36.700881 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:37.062712 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:37.353183 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:37.603193 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:37.802275 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:38.117845 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:38.359093 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:38.561712 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:38.8184 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:39.124959 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:39.429522 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:39.696787 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:39.965689 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:40.253465 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:40.60697 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:40.876228 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:41.104257 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:41.329096 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:41.610949 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:41.885715 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:42.118534 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:42.380492 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:42.597456 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:42.8191 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:43.024588 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:43.246063 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:43.537457 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:43.794561 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:44.0805 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:44.373045 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:44.608915 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:44.930553 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:45.134428 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:45.42525 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2025-03-25 20:04:45.708718 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:46.059115 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2025-03-25 20:04:46.300476 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2025-03-25 20:04:49.149295 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2025-03-25 20:04:49.193735 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2025-03-25 20:04:49.229884 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R Under development (unstable) (2025-03-01 r87860 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows Server 2022 x64 (build 20348)
##
## Matrix products: default
## LAPACK version 3.12.0
##
## locale:
## [1] LC_COLLATE=C
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.11.0 SummarizedExperiment_1.37.0
## [3] Biobase_2.67.0 GenomicRanges_1.59.1
## [5] GenomeInfoDb_1.43.4 IRanges_2.41.3
## [7] S4Vectors_0.45.4 BiocGenerics_0.53.6
## [9] generics_0.1.3 MatrixGenerics_1.19.1
## [11] matrixStats_1.5.0 BiocStyle_2.35.0
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.5 magrittr_2.0.3
## [7] compiler_4.5.0 RSQLite_2.3.9 mgcv_1.9-1
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.47.2 labeling_0.4.3
## [19] rmarkdown_2.29 UCSC.utils_1.3.1 preprocessCore_1.69.0
## [22] bit_4.6.0 xfun_0.51 cachem_1.1.0
## [25] jsonlite_1.9.1 blob_1.2.4 DelayedArray_0.33.6
## [28] BiocParallel_1.41.2 psych_2.5.3 Maaslin2_1.21.0
## [31] parallel_4.5.0 cluster_2.1.8.1 biglm_0.9-3
## [34] R6_2.6.1 RColorBrewer_1.1-3 bslib_0.9.0
## [37] stringi_1.8.4 rpart_4.1.24 jquerylib_0.1.4
## [40] Rcpp_1.0.14 bookdown_0.42 iterators_1.0.14
## [43] knitr_1.50 WGCNA_1.73 base64enc_0.1-3
## [46] Matrix_1.7-3 splines_4.5.0 nnet_7.3-20
## [49] tidyselect_1.2.1 rstudioapi_0.17.1 abind_1.4-8
## [52] yaml_2.3.10 doParallel_1.0.17 codetools_0.2-20
## [55] plyr_1.8.9 lattice_0.22-6 tibble_3.2.1
## [58] withr_3.0.2 KEGGREST_1.47.0 evaluate_1.0.3
## [61] foreign_0.8-89 survival_3.8-3 getopt_1.20.4
## [64] Biostrings_2.75.4 pillar_1.10.1 BiocManager_1.30.25
## [67] checkmate_2.3.2 foreach_1.5.2 pcaPP_2.0-5
## [70] ggplot2_3.5.1 munsell_0.5.1 scales_1.3.0
## [73] glue_1.8.0 Hmisc_5.2-3 tools_4.5.0
## [76] robustbase_0.99-4-1 data.table_1.17.0 mvtnorm_1.3-3
## [79] fastcluster_1.2.6 grid_4.5.0 optparse_1.7.5
## [82] impute_1.81.0 AnnotationDbi_1.69.0 colorspace_2.1-1
## [85] nlme_3.1-167 GenomeInfoDbData_1.2.14 htmlTable_2.4.3
## [88] Formula_1.2-5 cli_3.6.4 S4Arrays_1.7.3
## [91] dplyr_1.1.4 DEoptimR_1.1-3-1 gtable_0.3.6
## [94] hash_2.2.6.3 logging_0.10-108 dynamicTreeCut_1.63-1
## [97] sass_0.4.9 digest_0.6.37 SparseArray_1.7.7
## [100] farver_2.1.2 htmlwidgets_1.6.4 memoise_2.0.1
## [103] htmltools_0.5.8.1 lifecycle_1.0.4 httr_1.4.7
## [106] GO.db_3.21.0 bit64_4.6.0-1
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.