CHANGES IN VERSION 1.1.0 ------------------------ NEW FEATURES: - normalization can now be performed on individual channels (and channel pairs) - added semi-quantitative Quantitation with emPAI, dNSAF and spectral count - proteinInfo can now be gathered from Uniprot directly - added reporter intensity plot shpwing effect of normalization - added linear regression as ratio estimator - improved MA plot CHANGES IN VERSION 1.0.0 ------------------------ - first Bioconductor version (version bump to 1.0.0)! - slot name reporterMasses is renamed to reporterTagMasses to fix clash with method reporterMasses which fetches assayData(ibspectra)[["mass"]] - slot name reporterNames is renamed to reporterTagNames to distinguish from deprecated Biobase::reporterNames - added option 'scan.lines' to readIBSpectra: read mgf files in parts for large MGF files - use a function for protein reporting: create.reports.R properties.conf will be replaced by properties.R CHANGES IN VERSION 0.2.5 ------------------------ - MSnbase support: Added functions to coerce from MSnSet to IBSpectra and vice versa. Added Msnbase to Suggests. - support for multiple classes added - updated Perl parsers: mascotParser2.pl and pidresParser2.pl instead of isobarXParser.pl resulting XML files can be converted to id.csv using psx2tab2.pl - prob otion for readIBSpectra worked errornous - fixed (thanks to Xavier Robin) - added property use.na: Use NA values for quantification - various Analysis Report beautifications (thanks to Xavier Robin) - varous bug fixes CHANGES IN VERSION 0.2.4 ------------------------ - improved Vignette descriptions, added CITATION (still UTF-8 error) - added possibility to revert Mascot escaped TITLEs - if proteins are excluded w/ subsetIBSpectra, exclude all it's peptides, not only reporter-specific ones - fix error introduced in 0.2.3: When multiple MGFs were read, an false error occured that not all id spectra could be matched - add property 'author' for LaTeX reports - section 'Significantly regulated proteins' not shown anymore by default added property show.significant.proteins to reenable - added properties isotope.impurities and fragment.outlier.prob - bug fixes: - naming not correct when class labels contain NAs - numeric class labels are not handled correctly - added naRegion to noise model - data is now stored before normalization. Those values are then used to normalize. (Thanks to observation of Chris Bielow) CHANGES IN VERSION 0.2.3 ------------------------ - specify combination matrix for proteinRatios and in properties.conf - improved logging of IBSpectra creation and normalization - fix: maplot crashed on all NA channels - NA names in PDF report section 'Not quantified proteins' removed - allow for NA class labels - they are ignored in the comuptation of ratios CHANGES IN VERSION 0.2.2 ------------------------ - re-added ratio vs intensity plot in QC report - issue warning when summarize property is incorrectly defined - create cachedir if it does not exist - estimateRatio.group_specific_proteins renamed to quant.w.grouppeptides - sanitize analysisname, uniprotlink, and subsection names for LaTeX - use fancyhdr instead of fanctheadings - added argument require.reporter.specific to reporterProteins CHANGES IN VERSION 0.2.1 ------------------------ - Bug fix: as.data.frame generated ions/mass colnames with a 'X' in front CHANGES IN VERSION 0.2 ---------------------- - Published online with JPR Publication